Differential gene expression analyses have been performed on both
cancer vs. control tissues samples (E1) from TCGA and molecular compound treated cell line vs.
DMSO treated cell line (E2) from the CMap database.
When a cell line is treated with a compound,
if the effect on a gene is opposite, i.e., one up-regulated or 1 in E1 and the other
down-regulated or -1 in E2, or conversely, we consider it having a reversed effect on this gene.
Otherwise, if a gene is marked as 1(E1) ~1(E2), -1(E1) ~-1(E2), 0(E1) ~1(E2) or 0(E1) ~-1(E2)
with 0 for no change, we consider that the compound has an adverse effect on this gene.
ID: BRD-A03772856 | Dosage: 3 µM | Time: 6 h
Genes | Fold change of cancer samples vs. normal samples |
Fold change of compound treated vs. DMSO treated cell lines |
---|---|---|
ABCC4 | up 3.239 | down -3.188 |
ABCG2 | down -7.091 | up 5.817 |
ACACB | down -2.074 | up 2.623 |
ACSM1 | up 7.251 | down -4.74 |
ACTA2 | down -2.568 | up 3.004 |
ADGRG2 | down -2.288 | up 2.368 |
ADGRG6 | down -2.458 | up 5.327 |
ADGRV1 | up 2.147 | down -3.211 |
ADM2 | up 2.445 | down -3.997 |
ADORA2B | down -2.039 | up 2.527 |
ADRB1 | up 2.071 | down -6.136 |
AGMAT | up 2.408 | down -7.868 |
AGT | up 2.104 | down -12.363 |
AGTR1 | up 2.666 | down -6.806 |
AK5 | up 4.007 | down -4.237 |
AKR1B1 | down -14.798 | up 3.075 |
ALOX15 | up 3.443 | down -4.144 |
AMH | up 9.429 | down -7.904 |
ANK2 | down -2.596 | up 5.46 |
ANXA2P2 | down -2.658 | up 5.852 |
AOX1 | down -5.345 | up 3.189 |
APBA2 | up 2.258 | down -5.141 |
APOC1 | up 4.942 | down -8.711 |
APOF | up 5.369 | down -5.418 |
AQP2 | down -637.47 | up 5.055 |
ARC | down -7.025 | up 2.979 |
AREG | down -3.075 | up 17.19 |
ARHGDIG | up 6.589 | down -10.211 |
ARHGEF38 | up 2.933 | down -3.095 |
ASF1B | up 2.275 | down -3.329 |
ASIC2 | up 3.084 | down -6.348 |
ASIC3 | up 3.037 | down -5.752 |
ASMTL-AS1 | up 3.135 | down -3.007 |
ASPM | up 2.616 | down -3.404 |
ASPN | up 3.519 | down -4.666 |
ATOH1 | up 14.971 | down -2.512 |
ATP1B1 | down -2.213 | up 3.813 |
ATP6V0A4 | down -5.576 | up 10.478 |
AVPI1 | down -2.224 | up 11.061 |
B3GNT4 | up 2.022 | down -4.955 |
BAIAP2L2 | up 4.689 | down -2.891 |
BAIAP3 | up 2.12 | down -3.445 |
BDNF | down -2.431 | up 5.304 |
BEAN1 | up 2.074 | down -2.526 |
BICD1 | up 2.975 | down -2.914 |
BIK | up 2.214 | down -2.258 |
BMP6 | up 2.391 | down -4.329 |
BRSK2 | up 5.035 | down -2.425 |
C1orf106 | down -3.12 | up 16.074 |
C1QL1 | down -3.5 | up 3.038 |
C2orf72 | up 5.08 | down -14.159 |
C7 | down -2.279 | up 3.789 |
CA4 | down -3.52 | up 3.796 |
CACNA1D | up 4.459 | down -3.753 |
CAPG | down -2.324 | up 10.563 |
CASC5 | up 2.045 | down -4.003 |
CBLC | up 2.293 | down -3.516 |
CBS | up 2.468 | down -2.084 |
CBX2 | up 2.779 | down -3.481 |
CBX8 | up 2.144 | down -7.437 |
CCDC181 | down -2.409 | up 4.819 |
CCL11 | up 2.044 | down -8.421 |
CCL18 | up 3.907 | down -3.419 |
CCNA2 | up 2.478 | down -3.186 |
CDC25C | up 3.537 | down -3.736 |
CDH15 | up 2.613 | down -3.995 |
CDH7 | up 2.153 | down -5.503 |
CDHR1 | down -3.743 | up 2.022 |
CEACAM6 | down -2.848 | up 3.069 |
CELSR3 | up 3.383 | down -11.21 |
CENPF | up 2.966 | down -2.635 |
CES3 | up 2.248 | down -10.254 |
CGREF1 | up 3.933 | down -8.147 |
CHAD | down -2.139 | up 4.388 |
CHI3L1 | up 2.508 | down -10.741 |
CHIT1 | up 4.328 | down -2.761 |
CHRD | up 2.233 | down -2.041 |
CHRNA1 | up 2.49 | down -5.658 |
CLIP4 | down -2.218 | up 5.193 |
CLU | down -6.008 | up 5.874 |
COL17A1 | down -3.719 | up 2.885 |
COLEC12 | up 2.264 | down -3.42 |
CPEB1 | down -2.513 | up 4.356 |
CPNE7 | up 3.74 | down -2.161 |
CRABP1 | down -4.091 | up 3.08 |
CRABP2 | down -3.974 | up 7.252 |
CRHBP | down -2.828 | up 6.272 |
CRYAB | down -2.683 | up 3.173 |
CRYBA2 | up 3.08 | down -9.717 |
CSPG5 | up 2.179 | down -2.566 |
CST1 | up 4.695 | down -2.471 |
CST2 | up 14.181 | down -9.447 |
CST6 | down -3.889 | up 7.079 |
CTLA4 | up 2.313 | down -8.364 |
CXCL9 | up 2.021 | down -3.975 |
CXorf57 | down -2.709 | up 2.223 |
CYP2J2 | up 2.722 | down -7.864 |
CYP4B1 | down -4.508 | up 2.334 |
DCSTAMP | up 3.052 | down -7.938 |
DDIT4 | down -2.291 | up 3.786 |
DEFB1 | down -2.284 | up 9.033 |
DGCR9 | up 3.654 | down -4.829 |
DIRAS2 | up 2.447 | down -4.762 |
DKK1 | down -2.822 | up 3.909 |
DLGAP2 | up 2.232 | down -2.352 |
DLX2 | up 9.489 | down -7.364 |
DNAJC15 | down -2.454 | up 9.642 |
DNASE2B | up 2.982 | down -7.697 |
DOK4 | down -2.143 | up 4.083 |
DPYS | down -2.65 | up 3.423 |
DTNA | down -2.51 | up 3.655 |
DUSP4 | down -3.431 | up 4.107 |
EBF2 | up 4.787 | down -9.582 |
ECEL1 | up 2.153 | down -9.124 |
EDIL3 | down -2.289 | up 4.212 |
EDNRA | down -2.492 | up 2.517 |
EFHD1 | down -2.38 | up 6.488 |
ELAVL2 | up 4.871 | down -4.412 |
ELF5 | down -3.573 | up 2.478 |
EN2 | up 5.967 | down -11.015 |
EPHA2 | down -3.781 | up 4.476 |
ESPL1 | up 2.483 | down -3.296 |
EYA4 | down -3.284 | up 4.019 |
F12 | up 3.812 | down -3.916 |
F2RL2 | up 4.235 | down -5.79 |
F5 | up 2.814 | down -8.891 |
FAM189A1 | up 2.318 | down -6.649 |
FAM46A | down -2.39 | up 9.397 |
FAT4 | down -2.253 | up 7.282 |
FERMT2 | down -2.509 | up 3.362 |
FEV | up 3.896 | down -10.3 |
FFAR2 | up 3.452 | down -6.258 |
FGF17 | up 2.333 | down -6.019 |
FLNA | down -2.799 | up 6.278 |
FLRT3 | down -2.456 | up 5.795 |
FOLH1B | up 3.73 | down -7.214 |
FOLR1 | down -4.848 | up 9.41 |
FOXF1 | down -2.117 | up 2.163 |
FOXL2 | up 5.186 | down -2.811 |
FUT6 | down -5.024 | up 2.268 |
FXYD6 | down -3.097 | up 6.451 |
GABRD | up 3.674 | down -13.931 |
GADD45G | up 2.011 | down -6.021 |
GALNT6 | down -2.213 | up 5.009 |
GATM | down -2.688 | up 4.969 |
GCNT1 | up 3.042 | down -4.154 |
GFRA2 | down -3.114 | up 2.751 |
GJA3 | up 4.081 | down -8.57 |
GJB1 | up 2.686 | down -4.289 |
GLP1R | up 2.976 | down -5.679 |
GNMT | up 2.118 | down -2.686 |
GOLM1 | up 3.394 | down -2.614 |
GPM6A | down -3.135 | up 3.028 |
GPRC5A | down -2.058 | up 8.313 |
GPRC5D | up 2.091 | down -6.703 |
GPX3 | down -2.147 | up 2.385 |
GRM4 | up 2.445 | down -6.293 |
GRPR | up 4.19 | down -4.205 |
GSTM3 | down -4.911 | up 3.122 |
GSTP1 | down -4.174 | up 10.386 |
GTSE1 | up 3.823 | down -2.307 |
HCN2 | up 2.81 | down -10.001 |
HEY2 | up 2.215 | down -2.469 |
HIST1H2AI | up 2.789 | down -6.186 |
HIST1H2BN | up 2.205 | down -3.464 |
HMMR | up 2.654 | down -2.351 |
HOXA7 | down -2.359 | up 4.515 |
HOXB5 | down -11.565 | up 2.019 |
HOXB6 | down -24.413 | up 7.547 |
HOXB7 | down -5.896 | up 2.962 |
HOXB9 | down -13.626 | up 2.579 |
HOXC4 | up 4.98 | down -7.323 |
HP | up 2.72 | down -8.625 |
HPD | down -2.811 | up 3.891 |
HPN | up 5.672 | down -2.208 |
HRH3 | up 2.254 | down -4.139 |
HSF4 | up 3 | down -6.74 |
HSPA4L | down -2.691 | up 4.847 |
ID1 | down -2.773 | up 2.526 |
ID3 | down -2.335 | up 2.662 |
IER3 | down -3.242 | up 4.486 |
IGF2BP2 | down -2.052 | up 4.551 |
IL5RA | up 3.678 | down -2.245 |
INHA | up 2.205 | down -6.854 |
INSL5 | up 2.728 | down -6.648 |
INSM1 | up 3.068 | down -7.145 |
ITGA9 | down -2.297 | up 5.864 |
ITGB6 | down -2.841 | up 2.372 |
ITGB8 | down -2.373 | up 5.032 |
IZUMO4 | up 2.159 | down -2.054 |
KANK2 | down -2.351 | up 4.931 |
KCNN2 | up 2.159 | down -2.649 |
KIF18B | up 3.877 | down -2.684 |
KIF20A | up 2.927 | down -4.219 |
KIF25 | up 4.07 | down -8.507 |
KIF2C | up 2.12 | down -5.019 |
KIFC1 | up 2.651 | down -3.586 |
KLK15 | up 4.129 | down -3.404 |
KRT7 | down -3.181 | up 6.487 |
L1CAM | down -2.405 | up 8.559 |
LFNG | up 2.18 | down -4.157 |
LINC00939 | up 5.999 | down -3.418 |
LIPC | down -3.557 | up 2.828 |
LMO3 | down -4.537 | up 4.48 |
LMX1B | up 7.413 | down -6.518 |
LPAR1 | down -2.219 | up 3.289 |
LRRC17 | down -2.293 | up 5.244 |
LRRC31 | up 2.24 | down -3.106 |
LUZP2 | up 3.728 | down -2.478 |
MAK | up 3.011 | down -2.71 |
MAPK8IP2 | up 2.509 | down -7.353 |
MARCO | down -2.143 | up 8.618 |
MATK | up 5.983 | down -7.522 |
MBNL2 | down -2.089 | up 3.049 |
MCAM | down -2.096 | up 3.788 |
ME1 | down -3.542 | up 2.203 |
MICAL2 | up 2.002 | down -4.065 |
MLC1 | down -3.421 | up 2.382 |
MMP10 | up 2.238 | down -5.928 |
MMP26 | up 8.47 | down -9.528 |
MMP9 | up 2.966 | down -4.344 |
MNX1 | up 4.631 | down -7.376 |
MON1B | up 2.942 | down -5.506 |
MPP2 | down -2.729 | up 3.039 |
MRPL41 | up 2.435 | down -4.378 |
MSLN | down -6.384 | up 7.648 |
MTG1 | up 2.037 | down -11.167 |
MUC2 | up 2.273 | down -3.639 |
MXRA7 | down -2.314 | up 2.617 |
MYBL2 | up 5.134 | down -2.02 |
MYL5 | up 2.169 | down -8.354 |
MYL9 | down -2.507 | up 3.857 |
MYRIP | up 2.031 | down -8.286 |
MZB1 | up 2.901 | down -2.858 |
NAV2 | down -2.634 | up 2.066 |
NCALD | up 2.068 | down -2.261 |
NDNF | down -2.469 | up 4.546 |
NEAT1 | up 2.392 | down -6.817 |
NKX2-2 | up 15.698 | down -2.452 |
NKX3-2 | up 2.084 | down -9.036 |
NTRK2 | down -2.159 | up 2.715 |
ONECUT2 | up 9.865 | down -3.765 |
PALLD | down -2.79 | up 9.519 |
PAX1 | up 24.788 | down -6.423 |
PCBP3 | up 2.171 | down -2.906 |
PCDHA2 | up 2.927 | down -4.665 |
PCDHA6 | up 2.339 | down -2.525 |
PCDHB11 | up 2.509 | down -12.723 |
PCDHB3 | up 2.124 | down -4.202 |
PCDHB8 | up 3.7 | down -5.542 |
PCDHGA1 | up 2.625 | down -6.461 |
PCSK1N | up 2.299 | down -6.455 |
PCSK6 | up 3.061 | down -6.735 |
PCYT1B | down -2.807 | up 2.08 |
PDGFC | down -2.03 | up 2.027 |
PDIA2 | up 16.731 | down -7.412 |
PDK4 | down -8.221 | up 2.067 |
PDLIM5 | up 3.023 | down -4.496 |
PFKFB3 | down -2.11 | up 3.292 |
PILRB | up 2.36 | down -5.071 |
PIPOX | down -2.314 | up 6.925 |
PKMYT1 | up 2.53 | down -8.245 |
PLA2G2A | up 3.469 | down -11.829 |
PLA2G2D | up 2.474 | down -2.234 |
PLA2G7 | up 3.318 | down -3.629 |
PLEKHA2 | down -2.448 | up 4.719 |
PLEKHS1 | up 2.062 | down -3.462 |
PLLP | down -3.381 | up 5.036 |
PLPPR1 | up 3.288 | down -2.821 |
PLS3 | down -2.157 | up 5.332 |
PMP2 | down -2.97 | up 2.047 |
PNMA1 | down -2.021 | up 2.95 |
PNMAL1 | down -2.21 | up 7.389 |
POLQ | up 2.247 | down -4.073 |
PPARGC1A | down -3.37 | up 5.396 |
PPFIA2 | up 5.649 | down -3.222 |
PPM1E | up 2.382 | down -2.566 |
PRAME | up 7.193 | down -3.571 |
PRKCA | down -2.223 | up 3.099 |
PRLR | down -3.418 | up 4.48 |
PROM1 | down -2.693 | up 6.664 |
PRPS2 | down -2.412 | up 11.742 |
PRR16 | up 3.583 | down -9.164 |
PRR36 | up 3.443 | down -2.872 |
PRRG4 | down -2.223 | up 4.549 |
PRSS12 | down -2.131 | up 10.409 |
PTP4A3 | up 2.779 | down -5.218 |
PTPRR | up 3.33 | down -3.055 |
PTPRT | up 2.176 | down -2.826 |
PVT1 | up 2.354 | down -6.396 |
QPRT | down -5.319 | up 4.825 |
RAB26 | up 2.415 | down -10.384 |
RAB38 | down -2.758 | up 2.502 |
RAC3 | up 2.52 | down -6.917 |
RAD51 | up 2.088 | down -9.499 |
RAMP1 | up 2.207 | down -2.5 |
RASAL1 | down -8.546 | up 2.804 |
RBP1 | down -2.764 | up 6.043 |
RET | up 2.697 | down -3.961 |
REXO2 | up 2.042 | down -3.746 |
RGS11 | up 3.354 | down -9.706 |
RGS13 | down -2.27 | up 3.411 |
RGS9 | down -2.384 | up 3.786 |
RHCG | down -4.043 | up 6.536 |
RND2 | down -2.758 | up 2.101 |
ROPN1B | up 2.925 | down -2.467 |
RPGRIP1 | up 2.168 | down -4.788 |
RPL36A | up 2.13 | down -5.075 |
RRM2 | up 4.032 | down -9.913 |
S100A2 | down -2.173 | up 2.891 |
SCARA3 | down -3.363 | up 2.087 |
SCGB1A1 | down -5.573 | up 3.604 |
SCIN | up 2.084 | down -4.795 |
SCNN1A | down -2.226 | up 13.867 |
SCNN1D | up 2.537 | down -7.702 |
SDPR | down -2.557 | up 11.885 |
SDS | up 2.776 | down -8.843 |
SEC14L5 | up 2.091 | down -4.053 |
SEC23A | down -2.148 | up 8.887 |
SEMA5A | down -2.166 | up 3.742 |
SERPINA5 | down -111.519 | up 2.802 |
SERPINB1 | down -2.22 | up 2.745 |
SFTPA2 | up 4.066 | down -2.432 |
SLC16A4 | down -2.138 | up 4.187 |
SLC16A8 | up 2.77 | down -4.943 |
SLC19A1 | up 2.722 | down -2.881 |
SLC25A10 | up 2.212 | down -4.698 |
SLC25A22 | up 2.103 | down -13.084 |
SLC26A1 | up 2.151 | down -8.562 |
SLC26A6 | up 2.54 | down -8.719 |
SLC43A1 | up 2.882 | down -3.772 |
SLC4A10 | up 2.043 | down -2.694 |
SLC4A4 | up 2.174 | down -12.63 |
SLC6A11 | up 3.096 | down -9.251 |
SLC6A3 | up 3.52 | down -2.404 |
SLC7A11 | up 3.074 | down -2.626 |
SLIT1 | up 7.824 | down -3.53 |
SLPI | down -11.983 | up 2.559 |
SNX7 | down -2.112 | up 3.453 |
SOX14 | up 3.726 | down -2.263 |
SOX15 | down -2.617 | up 4.836 |
SPEF1 | up 2.267 | down -5.358 |
SPON2 | up 4.946 | down -2.778 |
SSTR1 | up 4.107 | down -3.482 |
ST18 | up 2.526 | down -8.951 |
STARD8 | down -2.331 | up 2.858 |
STK26 | down -2.293 | up 8.748 |
SULT4A1 | up 4.99 | down -6.551 |
SV2C | up 2.041 | down -9.504 |
SYP | up 2.024 | down -9.902 |
TAGLN | down -2.549 | up 5.603 |
TBX10 | up 6.59 | down -9.364 |
TDRD1 | up 7.86 | down -2.89 |
TENM1 | up 3.604 | down -5.806 |
THPO | up 2.764 | down -2.261 |
TIMP4 | down -2.212 | up 2.183 |
TINAGL1 | down -2.295 | up 6.599 |
TMEM100 | down -3.594 | up 4.822 |
TMOD2 | down -2.07 | up 2.673 |
TNN | up 4.942 | down -9.075 |
TOR4A | down -2.27 | up 4.259 |
TPM1 | down -2.684 | up 3.055 |
TPO | up 3.419 | down -4.187 |
TRIB1 | up 2.678 | down -15.707 |
TRIB3 | up 2.035 | down -24.918 |
TRIM29 | down -3.022 | up 5.758 |
TRIM36 | up 2.84 | down -5.002 |
TROAP | up 3.545 | down -3.604 |
TRPC1 | down -2.125 | up 7.289 |
TRPM2 | up 2.684 | down -6.881 |
TRPM8 | up 2.395 | down -4.079 |
TSPAN1 | up 2.384 | down -3.265 |
TTR | up 4.137 | down -11.15 |
UCN | up 4.689 | down -9.272 |
ULBP2 | up 2.895 | down -4.934 |
UNC5B | down -4.668 | up 2.403 |
VAX2 | up 2.997 | down -5.445 |
VCL | down -2.616 | up 3.646 |
YBX2 | down -2.02 | up 2.958 |
ZFHX4 | down -2.275 | up 3.311 |
ZMYND10 | up 4.246 | down -5.429 |
ZNF185 | down -4.044 | up 11.995 |
ZNF536 | down -2.865 | up 8.11 |
ZNF692 | up 2.173 | down -2.268 |
Genes | Fold change of cancer samples vs. normal samples |
Fold change of compound treated vs. DMSO treated cell lines |
---|---|---|
CHST2 | down -2.377 | down -21.002 |
CORO2B | down -2.551 | down -15.535 |
DYNC1I1 | down -2.304 | down -18.059 |
ID4 | down -3.099 | down -15.455 |
reverse gene |
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adverse gene |
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