Compound Detail

Differential gene expression analyses have been performed on both cancer vs. control tissues samples (E1) from TCGA and molecular compound treated cell line vs. DMSO treated cell line (E2) from the CMap database.
When a cell line is treated with a compound, if the effect on a gene is opposite, i.e., one up-regulated or 1 in E1 and the other down-regulated or -1 in E2, or conversely, we consider it having a reversed effect on this gene. Otherwise, if a gene is marked as 1(E1) ~1(E2), -1(E1) ~-1(E2), 0(E1) ~1(E2) or 0(E1) ~-1(E2) with 0 for no change, we consider that the compound has an adverse effect on this gene.

BRD-A03772856

ID: BRD-A03772856 | Dosage: 3 µM | Time: 6 h

Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines
ABCC4 up 3.239 down -3.188
ABCG2 down -7.091 up 5.817
ACACB down -2.074 up 2.623
ACSM1 up 7.251 down -4.74
ACTA2 down -2.568 up 3.004
ADGRG2 down -2.288 up 2.368
ADGRG6 down -2.458 up 5.327
ADGRV1 up 2.147 down -3.211
ADM2 up 2.445 down -3.997
ADORA2B down -2.039 up 2.527
ADRB1 up 2.071 down -6.136
AGMAT up 2.408 down -7.868
AGT up 2.104 down -12.363
AGTR1 up 2.666 down -6.806
AK5 up 4.007 down -4.237
AKR1B1 down -14.798 up 3.075
ALOX15 up 3.443 down -4.144
AMH up 9.429 down -7.904
ANK2 down -2.596 up 5.46
ANXA2P2 down -2.658 up 5.852
AOX1 down -5.345 up 3.189
APBA2 up 2.258 down -5.141
APOC1 up 4.942 down -8.711
APOF up 5.369 down -5.418
AQP2 down -637.47 up 5.055
ARC down -7.025 up 2.979
AREG down -3.075 up 17.19
ARHGDIG up 6.589 down -10.211
ARHGEF38 up 2.933 down -3.095
ASF1B up 2.275 down -3.329
ASIC2 up 3.084 down -6.348
ASIC3 up 3.037 down -5.752
ASMTL-AS1 up 3.135 down -3.007
ASPM up 2.616 down -3.404
ASPN up 3.519 down -4.666
ATOH1 up 14.971 down -2.512
ATP1B1 down -2.213 up 3.813
ATP6V0A4 down -5.576 up 10.478
AVPI1 down -2.224 up 11.061
B3GNT4 up 2.022 down -4.955
BAIAP2L2 up 4.689 down -2.891
BAIAP3 up 2.12 down -3.445
BDNF down -2.431 up 5.304
BEAN1 up 2.074 down -2.526
BICD1 up 2.975 down -2.914
BIK up 2.214 down -2.258
BMP6 up 2.391 down -4.329
BRSK2 up 5.035 down -2.425
C1orf106 down -3.12 up 16.074
C1QL1 down -3.5 up 3.038
C2orf72 up 5.08 down -14.159
C7 down -2.279 up 3.789
CA4 down -3.52 up 3.796
CACNA1D up 4.459 down -3.753
CAPG down -2.324 up 10.563
CASC5 up 2.045 down -4.003
CBLC up 2.293 down -3.516
CBS up 2.468 down -2.084
CBX2 up 2.779 down -3.481
CBX8 up 2.144 down -7.437
CCDC181 down -2.409 up 4.819
CCL11 up 2.044 down -8.421
CCL18 up 3.907 down -3.419
CCNA2 up 2.478 down -3.186
CDC25C up 3.537 down -3.736
CDH15 up 2.613 down -3.995
CDH7 up 2.153 down -5.503
CDHR1 down -3.743 up 2.022
CEACAM6 down -2.848 up 3.069
CELSR3 up 3.383 down -11.21
CENPF up 2.966 down -2.635
CES3 up 2.248 down -10.254
CGREF1 up 3.933 down -8.147
CHAD down -2.139 up 4.388
CHI3L1 up 2.508 down -10.741
CHIT1 up 4.328 down -2.761
CHRD up 2.233 down -2.041
CHRNA1 up 2.49 down -5.658
CLIP4 down -2.218 up 5.193
CLU down -6.008 up 5.874
COL17A1 down -3.719 up 2.885
COLEC12 up 2.264 down -3.42
CPEB1 down -2.513 up 4.356
CPNE7 up 3.74 down -2.161
CRABP1 down -4.091 up 3.08
CRABP2 down -3.974 up 7.252
CRHBP down -2.828 up 6.272
CRYAB down -2.683 up 3.173
CRYBA2 up 3.08 down -9.717
CSPG5 up 2.179 down -2.566
CST1 up 4.695 down -2.471
CST2 up 14.181 down -9.447
CST6 down -3.889 up 7.079
CTLA4 up 2.313 down -8.364
CXCL9 up 2.021 down -3.975
CXorf57 down -2.709 up 2.223
CYP2J2 up 2.722 down -7.864
CYP4B1 down -4.508 up 2.334
DCSTAMP up 3.052 down -7.938
DDIT4 down -2.291 up 3.786
DEFB1 down -2.284 up 9.033
DGCR9 up 3.654 down -4.829
DIRAS2 up 2.447 down -4.762
DKK1 down -2.822 up 3.909
DLGAP2 up 2.232 down -2.352
DLX2 up 9.489 down -7.364
DNAJC15 down -2.454 up 9.642
DNASE2B up 2.982 down -7.697
DOK4 down -2.143 up 4.083
DPYS down -2.65 up 3.423
DTNA down -2.51 up 3.655
DUSP4 down -3.431 up 4.107
EBF2 up 4.787 down -9.582
ECEL1 up 2.153 down -9.124
EDIL3 down -2.289 up 4.212
EDNRA down -2.492 up 2.517
EFHD1 down -2.38 up 6.488
ELAVL2 up 4.871 down -4.412
ELF5 down -3.573 up 2.478
EN2 up 5.967 down -11.015
EPHA2 down -3.781 up 4.476
ESPL1 up 2.483 down -3.296
EYA4 down -3.284 up 4.019
F12 up 3.812 down -3.916
F2RL2 up 4.235 down -5.79
F5 up 2.814 down -8.891
FAM189A1 up 2.318 down -6.649
FAM46A down -2.39 up 9.397
FAT4 down -2.253 up 7.282
FERMT2 down -2.509 up 3.362
FEV up 3.896 down -10.3
FFAR2 up 3.452 down -6.258
FGF17 up 2.333 down -6.019
FLNA down -2.799 up 6.278
FLRT3 down -2.456 up 5.795
FOLH1B up 3.73 down -7.214
FOLR1 down -4.848 up 9.41
FOXF1 down -2.117 up 2.163
FOXL2 up 5.186 down -2.811
FUT6 down -5.024 up 2.268
FXYD6 down -3.097 up 6.451
GABRD up 3.674 down -13.931
GADD45G up 2.011 down -6.021
GALNT6 down -2.213 up 5.009
GATM down -2.688 up 4.969
GCNT1 up 3.042 down -4.154
GFRA2 down -3.114 up 2.751
GJA3 up 4.081 down -8.57
GJB1 up 2.686 down -4.289
GLP1R up 2.976 down -5.679
GNMT up 2.118 down -2.686
GOLM1 up 3.394 down -2.614
GPM6A down -3.135 up 3.028
GPRC5A down -2.058 up 8.313
GPRC5D up 2.091 down -6.703
GPX3 down -2.147 up 2.385
GRM4 up 2.445 down -6.293
GRPR up 4.19 down -4.205
GSTM3 down -4.911 up 3.122
GSTP1 down -4.174 up 10.386
GTSE1 up 3.823 down -2.307
HCN2 up 2.81 down -10.001
HEY2 up 2.215 down -2.469
HIST1H2AI up 2.789 down -6.186
HIST1H2BN up 2.205 down -3.464
HMMR up 2.654 down -2.351
HOXA7 down -2.359 up 4.515
HOXB5 down -11.565 up 2.019
HOXB6 down -24.413 up 7.547
HOXB7 down -5.896 up 2.962
HOXB9 down -13.626 up 2.579
HOXC4 up 4.98 down -7.323
HP up 2.72 down -8.625
HPD down -2.811 up 3.891
HPN up 5.672 down -2.208
HRH3 up 2.254 down -4.139
HSF4 up 3 down -6.74
HSPA4L down -2.691 up 4.847
ID1 down -2.773 up 2.526
ID3 down -2.335 up 2.662
IER3 down -3.242 up 4.486
IGF2BP2 down -2.052 up 4.551
IL5RA up 3.678 down -2.245
INHA up 2.205 down -6.854
INSL5 up 2.728 down -6.648
INSM1 up 3.068 down -7.145
ITGA9 down -2.297 up 5.864
ITGB6 down -2.841 up 2.372
ITGB8 down -2.373 up 5.032
IZUMO4 up 2.159 down -2.054
KANK2 down -2.351 up 4.931
KCNN2 up 2.159 down -2.649
KIF18B up 3.877 down -2.684
KIF20A up 2.927 down -4.219
KIF25 up 4.07 down -8.507
KIF2C up 2.12 down -5.019
KIFC1 up 2.651 down -3.586
KLK15 up 4.129 down -3.404
KRT7 down -3.181 up 6.487
L1CAM down -2.405 up 8.559
LFNG up 2.18 down -4.157
LINC00939 up 5.999 down -3.418
LIPC down -3.557 up 2.828
LMO3 down -4.537 up 4.48
LMX1B up 7.413 down -6.518
LPAR1 down -2.219 up 3.289
LRRC17 down -2.293 up 5.244
LRRC31 up 2.24 down -3.106
LUZP2 up 3.728 down -2.478
MAK up 3.011 down -2.71
MAPK8IP2 up 2.509 down -7.353
MARCO down -2.143 up 8.618
MATK up 5.983 down -7.522
MBNL2 down -2.089 up 3.049
MCAM down -2.096 up 3.788
ME1 down -3.542 up 2.203
MICAL2 up 2.002 down -4.065
MLC1 down -3.421 up 2.382
MMP10 up 2.238 down -5.928
MMP26 up 8.47 down -9.528
MMP9 up 2.966 down -4.344
MNX1 up 4.631 down -7.376
MON1B up 2.942 down -5.506
MPP2 down -2.729 up 3.039
MRPL41 up 2.435 down -4.378
MSLN down -6.384 up 7.648
MTG1 up 2.037 down -11.167
MUC2 up 2.273 down -3.639
MXRA7 down -2.314 up 2.617
MYBL2 up 5.134 down -2.02
MYL5 up 2.169 down -8.354
MYL9 down -2.507 up 3.857
MYRIP up 2.031 down -8.286
MZB1 up 2.901 down -2.858
NAV2 down -2.634 up 2.066
NCALD up 2.068 down -2.261
NDNF down -2.469 up 4.546
NEAT1 up 2.392 down -6.817
NKX2-2 up 15.698 down -2.452
NKX3-2 up 2.084 down -9.036
NTRK2 down -2.159 up 2.715
ONECUT2 up 9.865 down -3.765
PALLD down -2.79 up 9.519
PAX1 up 24.788 down -6.423
PCBP3 up 2.171 down -2.906
PCDHA2 up 2.927 down -4.665
PCDHA6 up 2.339 down -2.525
PCDHB11 up 2.509 down -12.723
PCDHB3 up 2.124 down -4.202
PCDHB8 up 3.7 down -5.542
PCDHGA1 up 2.625 down -6.461
PCSK1N up 2.299 down -6.455
PCSK6 up 3.061 down -6.735
PCYT1B down -2.807 up 2.08
PDGFC down -2.03 up 2.027
PDIA2 up 16.731 down -7.412
PDK4 down -8.221 up 2.067
PDLIM5 up 3.023 down -4.496
PFKFB3 down -2.11 up 3.292
PILRB up 2.36 down -5.071
PIPOX down -2.314 up 6.925
PKMYT1 up 2.53 down -8.245
PLA2G2A up 3.469 down -11.829
PLA2G2D up 2.474 down -2.234
PLA2G7 up 3.318 down -3.629
PLEKHA2 down -2.448 up 4.719
PLEKHS1 up 2.062 down -3.462
PLLP down -3.381 up 5.036
PLPPR1 up 3.288 down -2.821
PLS3 down -2.157 up 5.332
PMP2 down -2.97 up 2.047
PNMA1 down -2.021 up 2.95
PNMAL1 down -2.21 up 7.389
POLQ up 2.247 down -4.073
PPARGC1A down -3.37 up 5.396
PPFIA2 up 5.649 down -3.222
PPM1E up 2.382 down -2.566
PRAME up 7.193 down -3.571
PRKCA down -2.223 up 3.099
PRLR down -3.418 up 4.48
PROM1 down -2.693 up 6.664
PRPS2 down -2.412 up 11.742
PRR16 up 3.583 down -9.164
PRR36 up 3.443 down -2.872
PRRG4 down -2.223 up 4.549
PRSS12 down -2.131 up 10.409
PTP4A3 up 2.779 down -5.218
PTPRR up 3.33 down -3.055
PTPRT up 2.176 down -2.826
PVT1 up 2.354 down -6.396
QPRT down -5.319 up 4.825
RAB26 up 2.415 down -10.384
RAB38 down -2.758 up 2.502
RAC3 up 2.52 down -6.917
RAD51 up 2.088 down -9.499
RAMP1 up 2.207 down -2.5
RASAL1 down -8.546 up 2.804
RBP1 down -2.764 up 6.043
RET up 2.697 down -3.961
REXO2 up 2.042 down -3.746
RGS11 up 3.354 down -9.706
RGS13 down -2.27 up 3.411
RGS9 down -2.384 up 3.786
RHCG down -4.043 up 6.536
RND2 down -2.758 up 2.101
ROPN1B up 2.925 down -2.467
RPGRIP1 up 2.168 down -4.788
RPL36A up 2.13 down -5.075
RRM2 up 4.032 down -9.913
S100A2 down -2.173 up 2.891
SCARA3 down -3.363 up 2.087
SCGB1A1 down -5.573 up 3.604
SCIN up 2.084 down -4.795
SCNN1A down -2.226 up 13.867
SCNN1D up 2.537 down -7.702
SDPR down -2.557 up 11.885
SDS up 2.776 down -8.843
SEC14L5 up 2.091 down -4.053
SEC23A down -2.148 up 8.887
SEMA5A down -2.166 up 3.742
SERPINA5 down -111.519 up 2.802
SERPINB1 down -2.22 up 2.745
SFTPA2 up 4.066 down -2.432
SLC16A4 down -2.138 up 4.187
SLC16A8 up 2.77 down -4.943
SLC19A1 up 2.722 down -2.881
SLC25A10 up 2.212 down -4.698
SLC25A22 up 2.103 down -13.084
SLC26A1 up 2.151 down -8.562
SLC26A6 up 2.54 down -8.719
SLC43A1 up 2.882 down -3.772
SLC4A10 up 2.043 down -2.694
SLC4A4 up 2.174 down -12.63
SLC6A11 up 3.096 down -9.251
SLC6A3 up 3.52 down -2.404
SLC7A11 up 3.074 down -2.626
SLIT1 up 7.824 down -3.53
SLPI down -11.983 up 2.559
SNX7 down -2.112 up 3.453
SOX14 up 3.726 down -2.263
SOX15 down -2.617 up 4.836
SPEF1 up 2.267 down -5.358
SPON2 up 4.946 down -2.778
SSTR1 up 4.107 down -3.482
ST18 up 2.526 down -8.951
STARD8 down -2.331 up 2.858
STK26 down -2.293 up 8.748
SULT4A1 up 4.99 down -6.551
SV2C up 2.041 down -9.504
SYP up 2.024 down -9.902
TAGLN down -2.549 up 5.603
TBX10 up 6.59 down -9.364
TDRD1 up 7.86 down -2.89
TENM1 up 3.604 down -5.806
THPO up 2.764 down -2.261
TIMP4 down -2.212 up 2.183
TINAGL1 down -2.295 up 6.599
TMEM100 down -3.594 up 4.822
TMOD2 down -2.07 up 2.673
TNN up 4.942 down -9.075
TOR4A down -2.27 up 4.259
TPM1 down -2.684 up 3.055
TPO up 3.419 down -4.187
TRIB1 up 2.678 down -15.707
TRIB3 up 2.035 down -24.918
TRIM29 down -3.022 up 5.758
TRIM36 up 2.84 down -5.002
TROAP up 3.545 down -3.604
TRPC1 down -2.125 up 7.289
TRPM2 up 2.684 down -6.881
TRPM8 up 2.395 down -4.079
TSPAN1 up 2.384 down -3.265
TTR up 4.137 down -11.15
UCN up 4.689 down -9.272
ULBP2 up 2.895 down -4.934
UNC5B down -4.668 up 2.403
VAX2 up 2.997 down -5.445
VCL down -2.616 up 3.646
YBX2 down -2.02 up 2.958
ZFHX4 down -2.275 up 3.311
ZMYND10 up 4.246 down -5.429
ZNF185 down -4.044 up 11.995
ZNF536 down -2.865 up 8.11
ZNF692 up 2.173 down -2.268
Enrichment Result
GO
PID
KEGG
REACTOME
Pathway Name P-value Reverse Num Hit Num Gene List
Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines
CHST2 down -2.377 down -21.002
CORO2B down -2.551 down -15.535
DYNC1I1 down -2.304 down -18.059
ID4 down -3.099 down -15.455
Enrichment Result
GO
PID
KEGG
REACTOME
Pathway Name P-value Adverse num Hit num Gene List

reverse gene
Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines
adverse gene
Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines