Compound Detail

Differential gene expression analyses have been performed on both cancer vs. control tissues samples (E1) from TCGA and molecular compound treated cell line vs. DMSO treated cell line (E2) from the CMap database.
When a cell line is treated with a compound, if the effect on a gene is opposite, i.e., one up-regulated or 1 in E1 and the other down-regulated or -1 in E2, or conversely, we consider it having a reversed effect on this gene. Otherwise, if a gene is marked as 1(E1) ~1(E2), -1(E1) ~-1(E2), 0(E1) ~1(E2) or 0(E1) ~-1(E2) with 0 for no change, we consider that the compound has an adverse effect on this gene.

BRD-A03772856

ID: BRD-A03772856 | Dosage: 10 µM | Time: 6 h

Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines
ABCD2 down -2.326 up 5.243
ACOT11 down -2.268 up 5.193
ACOX2 down -2.934 up 3.15
ACSL6 down -32.703 up 5.405
ACSS3 down -2.319 up 7.785
ADAMTS5 down -3.533 up 3.34
ADGRA2 down -2.171 up 2.243
ADGRB3 down -2.684 up 3.51
ADGRF5 up 2.386 down -2.056
ADGRL3 down -2.878 up 6.168
ADRA1A down -4.085 up 3.795
ADRA1D down -2.894 up 3.481
ADRA2B down -2.707 up 9.748
AGMAT up 2.408 down -3.011
ALDH3A1 down -2.898 up 2.398
AMOT down -3.157 up 4.682
ANK2 down -2.596 up 13.779
ANP32E down -2.191 up 10.988
ANXA2P2 down -2.658 up 5.783
ANXA9 down -3.037 up 9.285
AOX1 down -5.345 up 4.173
APOBEC3F down -2.145 up 22.119
APOBR down -2.243 up 3.49
APOC1 up 4.942 down -10.377
AQP9 down -2.503 up 7.432
ARC down -7.025 up 7.814
AREG down -3.075 up 3.334
ARHGEF40 down -2.754 up 8.307
ASF1B up 2.275 down -3.546
ASPHD1 up 3.494 down -7.017
ASTN1 down -3.999 up 2.452
ATOH1 up 14.971 down -2.797
B3GALT2 down -2.829 up 4.765
B3GAT1 up 3.217 down -2.464
BAIAP3 up 2.12 down -3.183
BCHE down -3.471 up 5.696
BCO1 down -2.649 up 2.78
BHMT2 down -2.79 up 7.736
BRSK2 up 5.035 down -6.369
BUB1B up 2.785 down -2.154
C16orf59 up 2.728 down -3.157
C1orf106 down -3.12 up 5.822
C21orf62 down -5.628 up 9.506
C7 down -2.279 up 3.472
CALD1 down -2.436 up 7.04
CAMK1D down -2.032 up 4.077
CAND2 down -2.117 up 3.352
CAPN6 down -4.558 up 13.413
CARTPT down -3.792 up 4.538
CASQ2 down -2.488 up 6.009
CBX8 up 2.144 down -4.92
CCDC181 down -2.409 up 12.214
CCL11 up 2.044 down -5.392
CCL18 up 3.907 down -6.855
CCNA2 up 2.478 down -5.991
CDCA3 up 2.387 down -4.156
CDH22 down -2.091 up 8.15
CDHR1 down -3.743 up 9.292
CDK18 down -3.385 up 3.083
CDKL2 down -2.641 up 6.735
CDO1 down -4.862 up 11.051
CEND1 down -2.868 up 3.39
CENPA up 3.755 down -10.249
CENPM up 3.182 down -3.336
CERS4 up 2.051 down -3.203
CES3 up 2.248 down -3.439
CFD down -2.12 up 3.41
CHAD down -2.139 up 2.642
CHD5 down -2.253 up 7.727
CHEK1 down -3.302 up 3.591
CHRDL1 down -3.755 up 10.231
CHRNA5 up 2.075 down -3.252
CLIP3 down -2.687 up 5.346
CLU down -6.008 up 6.99
CNR1 down -2.026 up 5.971
CNTFR down -3.365 up 3.035
COL17A1 down -3.719 up 2.26
COL21A1 down -2.448 up 14.781
COLEC12 up 2.264 down -2.093
CORO2B down -2.551 up 2.894
CPB1 up 2.692 down -2.844
CPED1 down -2.572 up 7.22
CRTAC1 down -19.791 up 12.159
CRYAB down -2.683 up 11.421
CST4 down -5.083 up 3.162
CTLA4 up 2.313 down -8.638
CTNNA2 down -2.519 up 9.315
CXCL10 up 2.02 down -6.549
CXCL11 up 2.51 down -4.935
CXCL6 down -2.063 up 10.277
CXCL9 up 2.021 down -6.763
CXCR2 down -6.188 up 11.232
CYP27A1 down -2.083 up 7.345
CYP2E1 down -3.585 up 8.821
CYP2W1 down -2.416 up 19.826
CYP3A5 down -4.019 up 10.356
CYP4F3 down -3.706 up 8.663
DCN down -2.041 up 12.156
DCSTAMP up 3.052 down -10.153
DDIT4 down -2.291 up 4.142
DDO down -2.142 up 14.287
DEFB1 down -2.284 up 6.569
DES down -2.76 up 2.702
DGKG down -2.652 up 2.522
DIXDC1 down -2.078 up 7.23
DKK3 down -2.066 up 9.113
DLGAP2 up 2.232 down -3.532
DLX2 up 9.489 down -3.772
DMD down -2.942 up 10.836
DNAJB1 down -2.269 up 2.626
DNAJB4 down -2.421 up 3.896
DNASE1L2 up 2.883 down -8.097
DOK4 down -2.143 up 9.847
DPT down -3.173 up 4.331
DPYS down -2.65 up 3.253
DPYSL3 down -2.268 up 3.582
DUSP2 down -5.265 up 3.07
DUSP4 down -3.431 up 8.165
DYNC1I1 down -2.304 up 6.335
DZIP1 down -2.12 up 11.066
E2F2 up 2.052 down -4.421
EDNRA down -2.492 up 6.582
EDNRB down -2.994 up 6.341
EFEMP1 down -2.582 up 3.633
EFHC2 down -2.181 up 3.196
ELAVL2 up 4.871 down -2.002
ELAVL3 down -2.626 up 3.629
ELF5 down -3.573 up 6.96
ERBB4 down -3.729 up 3.634
ERN2 down -3.075 up 5.848
ESPL1 up 2.483 down -3.622
EXO1 up 2.473 down -5.003
EYA1 down -2.343 up 4.907
EYA4 down -3.284 up 5.313
FADS2 down -2.806 up 7.259
FAM46A down -2.39 up 7.113
FAM64A up 2.906 down -4.546
FAT2 down -3.657 up 2.198
FAT4 down -2.253 up 10.418
FAXDC2 down -2.667 up 8.737
FCER1A down -2.035 up 4.069
FEZ1 down -2.356 up 2.594
FGF2 down -2.231 up 6.183
FGF7 down -2.718 up 9.559
FHL1 down -2.814 up 5.866
FOLR1 down -4.848 up 5.306
FOXL2 up 5.186 down -2.413
FUT3 down -17.439 up 3.146
FUT6 down -5.024 up 9.38
FXYD6 down -3.097 up 2.324
G0S2 down -4.894 up 2.088
GABRB3 up 2.669 down -5.283
GABRD up 3.674 down -5.655
GAL up 5.298 down -2.808
GALNT6 down -2.213 up 8.044
GAS1 down -2.365 up 3.406
GATM down -2.688 up 4.123
GIPC2 down -2.348 up 3.368
GNMT up 2.118 down -4.594
GPM6A down -3.135 up 12.94
GPM6B down -2.255 up 3.073
GPR37 up 2.41 down -9.149
GPX2 down -5.766 up 4.945
GRPR up 4.19 down -2.254
GSTM5 down -2.623 up 8.117
HAAO down -2.07 up 4.735
HAPLN1 down -2.958 up 3.159
HAS2 down -2.47 up 8.558
HBB down -3.356 up 5.949
HEPH down -2.339 up 2.219
HEY2 up 2.215 down -2.014
HIF3A down -2.956 up 2.127
HIST1H1C up 2.121 down -10.962
HIST1H1E up 4.606 down -4.402
HJURP up 4.179 down -5.042
HLF down -2.26 up 6.824
HOXA7 down -2.359 up 16.106
HOXB3 down -3.076 up 4.623
HOXB9 down -13.626 up 9.919
HOXD3 down -2.756 up 4.969
HPD down -2.811 up 12.156
HPGD up 2.512 down -13.978
HR down -2.099 up 9.905
HRH2 down -2.616 up 9.435
HS3ST3A1 down -2.442 up 10.966
HSD11B1 down -2.571 up 5.901
HSF4 up 3 down -6.227
HSPB8 down -3.578 up 6.003
HUNK down -2.442 up 2.901
ID1 down -2.773 up 2.645
ID4 down -3.099 up 20.184
IER3 down -3.242 up 3.629
IGF2BP2 down -2.052 up 3.656
IL1R2 down -2.195 up 3.127
IL1RAPL1 up 2.98 down -12.94
IL1RL1 down -4.471 up 10.274
IL33 down -2.155 up 8.797
IL5RA up 3.678 down -2.334
INHA up 2.205 down -3.936
INSM1 up 3.068 down -2.123
IRAK3 down -2.173 up 6.181
IRF5 down -2.625 up 5.929
ISYNA1 down -2.375 up 8.612
ITGA2 down -2.517 up 7.5
ITGB3 down -2.709 up 5.831
ITGB8 down -2.373 up 5.348
ITIH5 down -2.304 up 2.505
KAT2A up 2.026 down -2.351
KCNJ16 down -40.317 up 9.186
KCNJ8 down -2.293 up 3.821
KCNK15 down -2.117 up 5.053
KCNMA1 down -2.601 up 3.928
KCNN2 up 2.159 down -5.705
KCNQ1 down -3.739 up 3.589
KIF20A up 2.927 down -2.86
KIF26B down -2.846 up 7.878
KIF2C up 2.12 down -2.363
KLK12 up 5.564 down -4.595
KRT23 down -3.172 up 5.122
KRT4 down -4.422 up 7.36
LDB3 down -3.125 up 3.834
LIPC down -3.557 up 9.929
LONRF3 down -2.621 up 3.965
LPA down -2.714 up 3.978
LRP1B down -3.172 up 8.028
LRP4 down -2.159 up 5.729
LRRC17 down -2.293 up 11.911
LRRN3 down -2.838 up 5.075
LY6D down -9.507 up 9.105
MAP1A down -2.882 up 6.687
MAPK8IP2 up 2.509 down -5.988
MARCO down -2.143 up 5.453
MASP1 down -2.625 up 4.861
MECOM down -2.741 up 3.989
METTL7A down -2.072 up 3.368
MFAP5 down -2.631 up 7.562
MKI67 up 2.849 down -4.616
MLC1 down -3.421 up 2.729
MMP10 up 2.238 down -7.501
MMP11 up 2.396 down -11.902
MMP9 up 2.966 down -2.057
MON1B up 2.942 down -4.794
MPP2 down -2.729 up 2.141
MR1 down -2.228 up 7.031
MSLN down -6.384 up 8.211
MSMB down -2.145 up 6.494
MTG1 up 2.037 down -7.294
MUC4 down -3.413 up 4.967
MUC6 down -31.227 up 14.223
MXRA7 down -2.314 up 2.398
MYBL2 up 5.134 down -6.37
MYH3 down -2.159 up 12.065
MYH6 down -5.756 up 2.648
MYL9 down -2.507 up 2.798
MZB1 up 2.901 down -17.18
NDRG2 down -2.479 up 4.363
NDRG4 down -10.301 up 4.943
NETO2 up 4.202 down -5.187
NID1 down -2.073 up 2.584
NKAIN1 up 4.774 down -4.611
NKX2-2 up 15.698 down -2.514
NKX3-2 up 2.084 down -9.632
NLGN3 down -2.352 up 4.532
NMUR1 down -2.514 up 8.673
NOX1 down -3.087 up 2.229
NPR2 down -2.07 up 5.882
NPY up 4.921 down -6.041
NR4A3 down -2.395 up 13.171
NRCAM down -2.434 up 2.173
NRXN1 down -2.738 up 2.213
NSUN5P1 up 2.554 down -2.469
NTF3 down -2.15 up 5.072
NTRK1 down -2.225 up 2.166
NTRK2 down -2.159 up 7.2
ODAM down -2.196 up 9.929
OGN down -2.542 up 6.184
OLFM4 down -4.046 up 7.577
P2RX5 up 3.103 down -27.547
PAOX up 2.019 down -5.205
PAX2 down -17.122 up 9.06
PCBP3 up 2.171 down -14.213
PCDH9 down -2.384 up 2.608
PCDHGA1 up 2.625 down -3.493
PCP4 down -2.61 up 3.253
PCSK6 up 3.061 down -3.9
PDZRN4 down -3.157 up 2.09
PEAK1 down -2.29 up 5.68
PENK down -4.494 up 11.128
PGC down -3.522 up 4.197
PGR down -2.847 up 4.748
PIK3R1 down -2.003 up 4.6
PILRB up 2.36 down -7.14
PIPOX down -2.314 up 7.022
PITX2 down -2.772 up 7.622
PKMYT1 up 2.53 down -5.178
PLA2G2D up 2.474 down -2.263
PLAG1 down -3.034 up 8.998
PLBD1 down -2.854 up 3.485
PLN down -2.451 up 4.381
PNMA1 down -2.021 up 5.609
PNMAL1 down -2.21 up 2.674
POF1B down -2.151 up 5.159
POLQ up 2.247 down -2.427
POPDC2 down -2.73 up 6.44
POU2F3 down -2.921 up 4.818
POU5F1B up 2.958 down -6.401
PPARGC1A down -3.37 up 9.379
PRKG1 down -2.99 up 3.246
PRR36 up 3.443 down -3.781
PTGES down -8.313 up 3.021
PTGIS down -2.497 up 4.879
PTGS2 down -8.244 up 4.732
PTPRT up 2.176 down -4.488
QPRT down -5.319 up 5.543
RAB40A down -2.792 up 5.052
RABEP2 up 2.121 down -3.438
RAPGEFL1 down -2.64 up 8.07
RBFOX1 down -3.152 up 2.641
RBMS3 down -2.548 up 3.478
RBP1 down -2.764 up 12.223
REEP1 down -2.242 up 3.215
REXO2 up 2.042 down -3.302
RGN down -2.354 up 5.853
RGS10 up 2.219 down -15.8
RGS13 down -2.27 up 3.13
RGS9 down -2.384 up 2.295
RHOB down -2.075 up 7.458
RND2 down -2.758 up 4.175
ROPN1B up 2.925 down -4.024
RPE65 down -4.588 up 6.327
RPGRIP1 up 2.168 down -6.659
S100A6 down -2.142 up 2.25
SALL1 down -2.4 up 7.016
SBSPON down -4.87 up 12.153
SCARA3 down -3.363 up 6.805
SCGB1A1 down -5.573 up 9.814
SCGB2A1 down -2.706 up 6.189
SCN5A down -3.402 up 8.746
SCN7A down -2.249 up 2.623
SCNN1A down -2.226 up 3.396
SDPR down -2.557 up 9.008
SEC14L5 up 2.091 down -8.417
SEC31B up 2.154 down -5.529
SEMA3D down -2.155 up 7.893
SEMA5A down -2.166 up 14.828
SEMG1 down -881.943 up 2.496
SEMG2 down -735.211 up 7.588
SERPINA1 down -3.037 up 4.406
SERPINA4 down -3.267 up 6.745
SERPINF2 down -3.072 up 7.868
SFTPA2 up 4.066 down -2.23
SGCA down -2.161 up 12.959
SGCG down -2.774 up 11.236
SGK1 down -2.173 up 7.532
SKAP1 down -2.119 up 8.857
SLC16A4 down -2.138 up 16.582
SLC16A7 down -2.017 up 4.184
SLC2A4 down -2.309 up 2.477
SLC34A2 down -9.153 up 6.467
SLC7A11 up 3.074 down -6.644
SLC8A1 down -2.687 up 2.085
SMPDL3B up 3.23 down -2.5
SNHG3 up 3.009 down -7.025
SOSTDC1 down -3.713 up 2.78
SOX5 down -2.115 up 2.467
SPOCK3 down -3.064 up 3.209
STARD8 down -2.331 up 5.088
SULT4A1 up 4.99 down -6.569
SV2C up 2.041 down -5.122
SYNC down -2.474 up 6.1
TACC1 down -2.026 up 2.022
TENM3 down -2.323 up 3.878
TGM4 down -6.254 up 3.649
TINAGL1 down -2.295 up 8.076
TK1 up 2.393 down -4.968
TLR2 down -2.728 up 2.687
TMEM100 down -3.594 up 7.62
TMEM132A up 3.237 down -8.607
TMEM47 down -2.037 up 16.82
TMOD2 down -2.07 up 6.454
TMPRSS4 down -3.584 up 4.959
TMSB15A up 2.782 down -5.096
TNS4 down -2.988 up 14.261
TOR4A down -2.27 up 2.471
TPX2 up 2.876 down -3.733
TRIB1 up 2.678 down -7.717
TRIB3 up 2.035 down -19.716
TRIM31 down -6.142 up 4.548
TRIM36 up 2.84 down -3.951
TRIM9 down -4.708 up 7.214
TRIP13 up 2.313 down -9.26
TRO down -2.165 up 3.509
TROAP up 3.545 down -3.993
TRPC1 down -2.125 up 9.871
TRPC4 down -2.236 up 7.205
TRPC6 down -2.787 up 2.327
TRPM2 up 2.684 down -7.774
TRPM4 up 3.331 down -4.193
TTK up 2.302 down -2.226
TUBB4A up 7.899 down -3.146
VTN down -2.937 up 10.957
WFDC2 down -4.909 up 4.836
ZBTB7C down -2.545 up 3.576
ZEB2 down -2.083 up 9.796
ZFHX4 down -2.275 up 10.405
ZFPM2 down -2.197 up 10.877
ZNF185 down -4.044 up 3.491
ZNF692 up 2.173 down -6.881
Enrichment Result
GO
PID
KEGG
REACTOME
Pathway Name P-value Reverse Num Hit Num Gene List
Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines
ADRA2A up 2.632 up 19.481
AMACR up 9.505 up 25.959
ASPH 0 0 down -16.696
CLDN3 up 2.203 up 20.161
F7 0 0 up 15.717
GJA1 down -2.464 down -16.491
H2AFJ up 2.223 up 16.75
IRX4 up 2.39 up 15.39
ITGBL1 up 2.995 up 34.328
MYRIP up 2.031 up 17.538
PRR16 up 3.583 up 16.536
RASGRF1 down -2.721 down -16.185
SLC6A11 up 3.096 up 22.026
TMEM158 down -2.159 down -15.998
TNFRSF10C 0 0 up 18.385
WWC3 down -2.626 down -16.434
Enrichment Result
GO
PID
KEGG
REACTOME
Pathway Name P-value Adverse num Hit num Gene List

reverse gene
Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines
adverse gene
Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines