Compound Detail

Differential gene expression analyses have been performed on both cancer vs. control tissues samples (E1) from TCGA and molecular compound treated cell line vs. DMSO treated cell line (E2) from the CMap database.
When a cell line is treated with a compound, if the effect on a gene is opposite, i.e., one up-regulated or 1 in E1 and the other down-regulated or -1 in E2, or conversely, we consider it having a reversed effect on this gene. Otherwise, if a gene is marked as 1(E1) ~1(E2), -1(E1) ~-1(E2), 0(E1) ~1(E2) or 0(E1) ~-1(E2) with 0 for no change, we consider that the compound has an adverse effect on this gene.

BRD-A03772856

ID: BRD-A03772856 | Dosage: 500 nM | Time: 6 h

Genes Fold change of
cancer samples vs. normal samples 		Fold change of
compound treated vs. DMSO treated cell lines
ABCC4 up 3.239 down -7.735
ACAN up 2.286 down -10.872
ACSL4 down -2.128 up 4.102
ACSM1 up 7.251 down -4.066
ADAM2 up 13.118 down -6.876
ADGRF5 up 2.386 down -7.723
ADGRV1 up 2.147 down -3.705
ADH1B down -3.095 up 2.863
ADM2 up 2.445 down -5.622
ADRB1 up 2.071 down -5.56
AGMAT up 2.408 down -4.469
AHNAK2 down -3.358 up 9.206
AK5 up 4.007 down -2.564
AKR1B1 down -14.798 up 3.213
ALDH3A1 down -2.898 up 6.834
ALOX15 up 3.443 down -4.275
AMH up 9.429 down -11.686
ANO1 down -7.409 up 5.551
ANP32E down -2.191 up 4.813
ANXA2P2 down -2.658 up 5.694
ANXA6 down -2.24 up 6.134
APBA2 up 2.258 down -12.446
APOC1 up 4.942 down -6.76
APOF up 5.369 down -9.351
AQP2 down -637.47 up 3.722
AQP5 down -4.608 up 3.871
AREG down -3.075 up 11.185
ARHGDIG up 6.589 down -4.474
ARHGEF38 up 2.933 down -6.897
ARHGEF40 down -2.754 up 6.279
ARL4D down -3.486 up 6.402
ART4 up 2.432 down -4.494
ASIC2 up 3.084 down -4.944
ASIC3 up 3.037 down -9.592
ASMTL-AS1 up 3.135 down -3.765
ASPA down -4.257 up 2.059
ASPHD1 up 3.494 down -2.517
ASPM up 2.616 down -2.625
ASPN up 3.519 down -4.745
ATP8A2 up 11.657 down -5.194
B3GNT3 down -2.464 up 4.422
B3GNT4 up 2.022 down -9.731
BAIAP2L2 up 4.689 down -6.519
BAIAP3 up 2.12 down -10.259
BANK1 up 3.24 down -6.002
BCAM up 2.029 down -5.867
BDNF down -2.431 up 6.023
BEAN1 up 2.074 down -9.99
BEX1 down -2.012 up 6.648
BGN up 2.011 down -6.465
BIRC5 up 3.842 down -2.361
BMP6 up 2.391 down -4.48
BUB1 up 2.573 down -2.16
BUB1B up 2.785 down -3.973
C14orf132 down -2.463 up 4.149
C16orf45 down -2.356 up 10.248
C1orf106 down -3.12 up 3.338
C2orf72 up 5.08 down -5.616
C4orf19 down -2.494 up 3.801
C5orf30 up 2.09 down -2.507
C7 down -2.279 up 8.609
CA10 up 2.531 down -6.221
CAND2 down -2.117 up 2.796
CAP2 down -2.139 up 7.038
CAPG down -2.324 up 7.521
CAPN6 down -4.558 up 8.017
CASC5 up 2.045 down -3.024
CASQ2 down -2.488 up 2.455
CBLC up 2.293 down -4.748
CBS up 2.468 down -2.963
CCKBR down -2.508 up 3.792
CCL11 up 2.044 down -9.921
CCL17 up 2.246 down -7.966
CCL18 up 3.907 down -4.321
CCNJL down -2.508 up 5.019
CDC45 up 2.585 down -3.194
CDH22 down -2.091 up 14.504
CDH7 up 2.153 down -4.882
CDHR1 down -3.743 up 4.102
CEACAM5 up 2.226 down -2.054
CENPF up 2.966 down -10.124
CERS4 up 2.051 down -7.356
CES3 up 2.248 down -6.417
CGA up 3.336 down -6.917
CHEK1 down -3.302 up 2.849
CHI3L1 up 2.508 down -3.269
CHIT1 up 4.328 down -6.706
CHST3 down -2.175 up 8.574
CLIC4 down -2.039 up 2.621
CLIP4 down -2.218 up 5.025
CLU down -6.008 up 2.494
COL10A1 up 4.775 down -3.434
COL9A2 up 4.77 down -4.017
COLEC12 up 2.264 down -2.519
CORO2B down -2.551 up 7.306
CPB1 up 2.692 down -5.197
CPNE6 down -4.555 up 3.742
CPNE7 up 3.74 down -9.037
CRYBA2 up 3.08 down -6.348
CSPG4 down -2.071 up 2.974
CST1 up 4.695 down -2.861
CST6 down -3.889 up 6.754
CTLA4 up 2.313 down -6.298
CXCL10 up 2.02 down -9.411
CXCL11 up 2.51 down -6.414
CXCL9 up 2.021 down -5.269
CYP24A1 down -2.234 up 2.863
DCSTAMP up 3.052 down -5.81
DEFB1 down -2.284 up 8.602
DIAPH3 up 2.023 down -3.052
DIO1 up 5.539 down -2.617
DIRAS2 up 2.447 down -9.797
DKK1 down -2.822 up 9.058
DLGAP2 up 2.232 down -2.965
DMBT1 down -4.804 up 7.224
DNAJC15 down -2.454 up 7.535
DNASE2B up 2.982 down -6.912
DTNA down -2.51 up 3.22
DUSP4 down -3.431 up 9.283
E2F2 up 2.052 down -3.729
EDN3 down -3.244 up 5.696
ELAVL2 up 4.871 down -4.045
ELAVL3 down -2.626 up 6.666
ELF5 down -3.573 up 9.032
EN2 up 5.967 down -3.876
ENTPD5 up 2.322 down -7.294
EPHA2 down -3.781 up 5.005
ERG up 5.594 down -9.135
ERN2 down -3.075 up 7.476
ETNK2 down -2.388 up 3.321
F5 up 2.814 down -3.668
FADS2 down -2.806 up 5.953
FAM189A1 up 2.318 down -9.79
FAM46A down -2.39 up 3.134
FAXDC2 down -2.667 up 2.616
FBXL8 up 2.264 down -2.547
FEV up 3.896 down -10.365
FFAR2 up 3.452 down -5.375
FLNC down -3.2 up 7.76
FOLH1B up 3.73 down -14.897
FOLR1 down -4.848 up 7.47
FOXD3 up 2.284 down -4.812
FSCN2 up 2.054 down -3.513
FUT2 down -3.224 up 5.549
GABRB3 up 2.669 down -2.755
GABRD up 3.674 down -6.229
GABRP down -2.2 up 2.931
GAD1 up 2.262 down -2.69
GADD45G up 2.011 down -2.277
GAS1 down -2.365 up 3.185
GATM down -2.688 up 10.071
GCNT1 up 3.042 down -9.282
GHRHR up 3.267 down -2.328
GJB1 up 2.686 down -9.686
GJB3 down -3.026 up 2.671
GJC1 down -2.262 up 3.369
GNAL down -2.69 up 2.249
GNMT up 2.118 down -5.404
GOLM1 up 3.394 down -4.841
GPR37 up 2.41 down -5.866
GPRC5A down -2.058 up 12.242
GPRC5D up 2.091 down -2.105
GRPR up 4.19 down -14.314
GSTM2 down -2.366 up 2.921
GSTM3 down -4.911 up 4.199
GSTM5 down -2.623 up 4.774
HABP2 up 5.29 down -2.801
HAND2 down -2.175 up 8.707
HCN2 up 2.81 down -6.529
HEY2 up 2.215 down -6.985
HIST1H1C up 2.121 down -2.663
HIST1H1E up 4.606 down -3.56
HIST1H2AE up 2.446 down -2.314
HIST1H2BG up 2.578 down -2.564
HIST1H2BN up 2.205 down -3.597
HOXA7 down -2.359 up 6.267
HPGD up 2.512 down -15.363
HPN up 5.672 down -2.721
HPX up 2.813 down -3.854
HR down -2.099 up 2.088
HRH3 up 2.254 down -2.79
ID3 down -2.335 up 6.559
ID4 down -3.099 up 10.267
IER3 down -3.242 up 5.105
IGF2BP2 down -2.052 up 6.904
IL11 up 2.548 down -5.507
IL5RA up 3.678 down -9.792
INHA up 2.205 down -3.783
INSM1 up 3.068 down -11.354
IRF5 down -2.625 up 3.263
ITGA2 down -2.517 up 4.915
ITGB4 down -2.102 up 4.598
ITGB8 down -2.373 up 4.337
ITIH5 down -2.304 up 4.388
IZUMO4 up 2.159 down -11.671
KANK2 down -2.351 up 4.841
KCNMB2 up 2.613 down -5.019
KCNN2 up 2.159 down -6.15
KCNQ1 down -3.739 up 2.874
KCNS1 down -6.79 up 2.598
KCTD14 down -4.015 up 3.369
KIF25 up 4.07 down -7.199
KIF4A up 3.416 down -2.741
KLHL35 up 3.226 down -2.142
KLK12 up 5.564 down -6.67
KLK14 up 4.47 down -4.779
KRT7 down -3.181 up 6.575
L1CAM down -2.405 up 5.15
LINC00115 up 2.295 down -4.348
LINC00939 up 5.999 down -3.966
LIPG down -7.103 up 2.351
LONRF3 down -2.621 up 12.063
LPL down -13.132 up 5.515
LRP4 down -2.159 up 5.38
LRRC17 down -2.293 up 2.901
LRRC31 up 2.24 down -3.032
LUZP2 up 3.728 down -9.219
MAK up 3.011 down -7.932
MASP1 down -2.625 up 2.212
MATK up 5.983 down -4.798
MCCC2 up 2.393 down -10.013
ME1 down -3.542 up 2.545
MICAL2 up 2.002 down -6.996
MIPEP up 3.244 down -9.702
MLC1 down -3.421 up 4.16
MMP10 up 2.238 down -8.95
MMP9 up 2.966 down -4.282
MNX1 up 4.631 down -3.39
MRPL41 up 2.435 down -2.566
MSLN down -6.384 up 8.364
MTG1 up 2.037 down -2.458
MUC13 up 2.637 down -4.726
MUC2 up 2.273 down -5.849
MXD3 up 2.657 down -3.652
MYL5 up 2.169 down -13.806
MYRIP up 2.031 down -11.046
MYT1 up 3.74 down -10.948
MZB1 up 2.901 down -6.832
NAV2 down -2.634 up 3.517
NCAM1 down -3.299 up 2.372
NDRG2 down -2.479 up 10.718
NEAT1 up 2.392 down -8.189
NEFM down -7.456 up 4.32
NEK2 up 3.063 down -7.593
NFE2L3 up 2.076 down -5.16
NKX2-2 up 15.698 down -5.28
NKX3-2 up 2.084 down -2.713
NOL4 up 4.13 down -9.031
NOX4 up 4.014 down -5.151
NPY up 4.921 down -3.255
NSUN5P1 up 2.554 down -7.155
ODAM down -2.196 up 4.341
OGN down -2.542 up 2.56
ONECUT2 up 9.865 down -3.128
OR51E2 up 5.291 down -4.228
P2RY2 down -3.059 up 6.395
PAOX up 2.019 down -14.85
PAX1 up 24.788 down -9.663
PAX2 down -17.122 up 4.688
PAX5 up 2.724 down -5.112
PAX8 down -9.117 up 4.766
PCBP3 up 2.171 down -7.299
PCDHA2 up 2.927 down -3.868
PCDHA6 up 2.339 down -2.492
PCDHB8 up 3.7 down -3.106
PCDHGA1 up 2.625 down -2.348
PDIA2 up 16.731 down -4.586
PEG3 down -2.202 up 2.585
PENK down -4.494 up 11.739
PHYHIP down -2.441 up 3.846
PINLYP down -2.108 up 3.471
PITX2 down -2.772 up 3.288
PLA2G2D up 2.474 down -4.094
PLA2G7 up 3.318 down -4.334
PLBD1 down -2.854 up 6.865
PLEKHA2 down -2.448 up 6.769
PLP1 down -2.771 up 6.034
PMP2 down -2.97 up 3.594
PNMA1 down -2.021 up 3.776
PNMA2 down -2.719 up 6.639
PNMAL1 down -2.21 up 5.308
POPDC3 up 2.183 down -5.007
POTEKP up 2.017 down -7.298
PPEF1 up 2.315 down -13.285
PPFIA2 up 5.649 down -13.011
PPM1E up 2.382 down -4.8
PRAME up 7.193 down -6.826
PRDM8 down -3.128 up 3.13
PRKCA down -2.223 up 8.324
PROC up 3.367 down -5.228
PRR16 up 3.583 down -5.649
PRR36 up 3.443 down -10.674
PRRG4 down -2.223 up 5.192
PTGES down -8.313 up 4.839
PTP4A3 up 2.779 down -10.51
PTPRR up 3.33 down -15.466
PVT1 up 2.354 down -7.108
QPRT down -5.319 up 9.529
RAB17 up 2.626 down -5.607
RAB26 up 2.415 down -7.903
RBFOX1 down -3.152 up 7.934
RBP1 down -2.764 up 9.281
REPS2 up 2.193 down -3.884
RGS11 up 3.354 down -6.828
RHOBTB2 down -2.396 up 6.62
RPGRIP1 up 2.168 down -10.382
S100A2 down -2.173 up 2.654
S100A6 down -2.142 up 6.835
S100B down -2.473 up 3.41
SCARA3 down -3.363 up 5.713
SCIN up 2.084 down -6.255
SCN2B down -3.095 up 6.159
SCNN1D up 2.537 down -7.609
SDS up 2.776 down -8.003
SEC14L5 up 2.091 down -6.973
SEC31B up 2.154 down -11.205
SEMA5A down -2.166 up 2.153
SERPINA5 down -111.519 up 10.379
SERPINB5 down -4.105 up 2.398
SFRP4 up 2.901 down -2.419
SGCB down -2.125 up 2.168
SGCE down -2.085 up 2.948
SGCG down -2.774 up 2.793
SLC16A5 down -3.106 up 4.982
SLC16A7 down -2.017 up 16.923
SLC24A3 down -2.258 up 2.125
SLC25A22 up 2.103 down -5.973
SLC26A1 up 2.151 down -3.783
SLC26A3 down -26.536 up 3.396
SLC34A2 down -9.153 up 4.871
SLC4A10 up 2.043 down -2.455
SLC6A3 up 3.52 down -6.118
SLC9A3 up 2.786 down -3.491
SLCO1A2 up 9.226 down -3.4
SLIT1 up 7.824 down -6.615
SLPI down -11.983 up 9.915
SNHG3 up 3.009 down -3.497
SNPH down -3.531 up 4.879
SOSTDC1 down -3.713 up 4.73
SOX14 up 3.726 down -4.725
SPON1 down -3.019 up 5.272
SSPN down -2.127 up 5.263
ST18 up 2.526 down -12.62
SV2C up 2.041 down -3.404
TACC1 down -2.026 up 2.008
TDO2 up 4.344 down -6.188
TDRD1 up 7.86 down -9.14
TENM1 up 3.604 down -16.648
TENM3 down -2.323 up 2.456
THPO up 2.764 down -4.804
TMC5 up 2.315 down -2.48
TMPRSS4 down -3.584 up 2.892
TMSB15A up 2.782 down -3.158
TNS4 down -2.988 up 4.379
TOX3 up 2.101 down -8.291
TPO up 3.419 down -3.275
TRIB1 up 2.678 down -11.235
TRIB3 up 2.035 down -20.82
TRIM29 down -3.022 up 5.491
TRIM36 up 2.84 down -3.751
TRIM9 down -4.708 up 3.235
TRIP13 up 2.313 down -2.743
TROAP up 3.545 down -2.137
TRPM8 up 2.395 down -3.861
TUBB4A up 7.899 down -11.517
TWIST1 up 4.473 down -12.104
VWA5A down -2.347 up 2.942
WFDC2 down -4.909 up 9.939
YPEL1 up 2.463 down -7.18
ZDHHC11 up 2.821 down -6.372
ZMYND10 up 4.246 down -14.61
ZNF185 down -4.044 up 11.114
ZNF516 down -2.426 up 8.833
ZNF692 up 2.173 down -4.377
Enrichment Result
GO
PID
KEGG
REACTOME
Pathway Name P-value Reverse Num Hit Num Gene List
Genes Fold change of
cancer samples vs. normal samples 		Fold change of
compound treated vs. DMSO treated cell lines
ANXA13 0 0 down -18.153
CNTN1 down -2.424 down -16.791
EFHC2 down -2.181 down -15.434
EGLN3 down -2.159 down -20.01
EYA1 down -2.343 down -16.025
HS3ST3A1 down -2.442 down -17.186
LARGE down -2.276 down -16.468
P2RX1 down -2.887 down -16.597
ROBO1 down -2.201 down -17.692
TAGLN3 0 0 down -16.694
Enrichment Result
GO
PID
KEGG
REACTOME
Pathway Name P-value Adverse num Hit num Gene List

reverse gene
Genes Fold change of
cancer samples vs. normal samples 		Fold change of
compound treated vs. DMSO treated cell lines
adverse gene
Genes Fold change of
cancer samples vs. normal samples 		Fold change of
compound treated vs. DMSO treated cell lines