Compound Detail

Differential gene expression analyses have been performed on both cancer vs. control tissues samples (E1) from TCGA and molecular compound treated cell line vs. DMSO treated cell line (E2) from the CMap database.
When a cell line is treated with a compound, if the effect on a gene is opposite, i.e., one up-regulated or 1 in E1 and the other down-regulated or -1 in E2, or conversely, we consider it having a reversed effect on this gene. Otherwise, if a gene is marked as 1(E1) ~1(E2), -1(E1) ~-1(E2), 0(E1) ~1(E2) or 0(E1) ~-1(E2) with 0 for no change, we consider that the compound has an adverse effect on this gene.

trichostatin-a

ID: BRD-A19037878 | Dosage: 3 µM | Time: 6 h

Genes Fold change of
cancer samples vs. normal samples 		Fold change of
compound treated vs. DMSO treated cell lines
ABCG2 down -7.091 up 20.928
ABHD6 down -2.564 up 31.448
ABO down -2.498 up 2.231
ACAN up 2.286 down -4.053
ACE down -2.542 up 8.164
ACOT11 down -2.268 up 7.121
ACSF2 down -2.713 up 6.468
ACSL6 down -32.703 up 2.827
ACTA2 down -2.568 up 6.069
ACTC1 down -5.897 up 7.891
ACTG2 down -3.174 up 14.351
ADGRG6 down -2.458 up 2.525
ADH1B down -3.095 up 4.736
ADRA1D down -2.894 up 3.827
ADRA2B down -2.707 up 12.481
AGMAT up 2.408 down -2.679
AGTR1 up 2.666 down -3.87
AJAP1 down -2.963 up 5.733
ALDH1A3 up 2.044 down -11.853
ALOX15 up 3.443 down -10.73
AMACR up 9.505 down -13.084
ANGPT1 down -4.18 up 13.619
ANK2 down -2.596 up 8.231
ANXA6 down -2.24 up 7.968
AOC3 down -2.13 up 12.136
AOX1 down -5.345 up 19.051
APBA2 up 2.258 down -2.202
APOB down -2.494 up 2.773
APOBEC3F down -2.145 up 8.725
APOBR down -2.243 up 8.189
AQP5 down -4.608 up 4.263
ARC down -7.025 up 12.6
AREG down -3.075 up 6.274
ARHGEF28 down -2.095 up 4.152
ARHGEF40 down -2.754 up 3.168
ARMCX1 down -2.342 up 2.238
ASB9 up 2.319 down -14.166
ASF1B up 2.275 down -12.813
ASPM up 2.616 down -4.773
ASPN up 3.519 down -4.318
ASS1 down -2.329 up 4.614
ASTN1 down -3.999 up 8.912
ATP1A2 down -3.073 up 2.976
ATP1B1 down -2.213 up 23.621
ATP2A3 down -2.251 up 13.645
ATP2B4 down -2.741 up 11.018
ATP6V0A4 down -5.576 up 10.487
ATP8A2 up 11.657 down -4.704
AURKB up 2.903 down -17.99
AVPI1 down -2.224 up 10.487
B3GALT2 down -2.829 up 14.142
BCO1 down -2.649 up 3.431
BDNF down -2.431 up 7.549
BHMT2 down -2.79 up 2.732
BICD1 up 2.975 down -8.045
BIRC5 up 3.842 down -8.655
BMP5 down -4.571 up 10.838
BOP1 up 2.362 down -4.273
BUB1 up 2.573 down -10.047
BUB1B up 2.785 down -2.214
C14orf132 down -2.463 up 17.674
C21orf62 down -5.628 up 13.323
C5orf30 up 2.09 down -2.802
C7 down -2.279 up 11.282
CA2 down -22.205 up 13.254
CA4 down -3.52 up 12.327
CACNA1D up 4.459 down -9.494
CALD1 down -2.436 up 3.913
CAMK1D down -2.032 up 12.563
CAMK1G down -2.499 up 3.078
CAMK4 down -2.013 up 2.364
CAMKK2 up 3.176 down -19.771
CAPG down -2.324 up 7.497
CAV1 down -3.292 up 7.33
CAV2 down -2.638 up 14.938
CAV3 down -2.223 up 13.838
CBLC up 2.293 down -4.255
CBR3 up 2.125 down -11.569
CCDC181 down -2.409 up 5.544
CCDC69 down -2.568 up 16.869
CCK down -3.591 up 10.749
CCL17 up 2.246 down -2.095
CCNA2 up 2.478 down -20.697
CCNB2 up 2.39 down -18.203
CCNJL down -2.508 up 7.532
CD177 down -3.03 up 2.049
CD40 down -2.068 up 2.385
CDC25C up 3.537 down -4.319
CDC45 up 2.585 down -4.73
CDCA3 up 2.387 down -8.138
CDCA8 up 2.396 down -5.398
CDH22 down -2.091 up 4.57
CDH7 up 2.153 down -8.055
CDHR1 down -3.743 up 2.604
CDK18 down -3.385 up 9.701
CDK5R1 up 2.238 down -5.462
CDKL2 down -2.641 up 5.96
CDO1 down -4.862 up 5.039
CEACAM5 up 2.226 down -2.656
CEND1 down -2.868 up 13.866
CENPF up 2.966 down -9.961
CENPN up 2.519 down -17.82
CENPU up 2.058 down -8.277
CERK down -2.329 up 6.865
CFD down -2.12 up 3.381
CGREF1 up 3.933 down -3.666
CHD5 down -2.253 up 8.27
CHIT1 up 4.328 down -4.006
CHRD up 2.233 down -4.944
CHRNA5 up 2.075 down -2.074
CHST11 down -2.354 up 6.525
CLCA2 down -7.995 up 3.193
CLCA4 down -5.663 up 7.159
CLIC4 down -2.039 up 13.587
CLIP3 down -2.687 up 3.297
CLSTN2 down -2.052 up 8.802
CLU down -6.008 up 4.332
CNTN1 down -2.424 up 5.182
COL21A1 down -2.448 up 4.17
COL9A1 down -2.366 up 9.394
COMP up 4.469 down -5.159
CORO2B down -2.551 up 2.46
CPED1 down -2.572 up 4.66
CPNE6 down -4.555 up 8.602
CRABP1 down -4.091 up 4.351
CRABP2 down -3.974 up 4.826
CRTAC1 down -19.791 up 8.732
CSPG4 down -2.071 up 7.228
CSRP1 down -2.737 up 6.245
CST6 down -3.889 up 3.445
CTF1 down -2.396 up 7.209
CXCL13 down -3.119 up 8.585
CYP11A1 down -3.19 up 6.081
CYP26B1 down -3.72 up 9.62
CYP2W1 down -2.416 up 8.445
CYP3A5 down -4.019 up 6.532
DAAM2 down -3.244 up 9.806
DAB1 down -2.869 up 3.152
DCN down -2.041 up 14.516
DDIT4 down -2.291 up 12.285
DDR2 down -2.293 up 12.424
DGCR9 up 3.654 down -2.684
DIXDC1 down -2.078 up 3.201
DKK3 down -2.066 up 16.032
DLGAP5 up 3.082 down -14.672
DMBT1 down -4.804 up 8.538
DNAJB1 down -2.269 up 8.459
DNAJB4 down -2.421 up 16.422
DNAJB5 down -2.679 up 5.82
DNAJC15 down -2.454 up 4.263
DOCK3 down -2.567 up 2.876
DOK4 down -2.143 up 10.211
DPP6 down -4.648 up 2.946
DPYS down -2.65 up 3.918
DRD2 down -3.01 up 3.569
DTNA down -2.51 up 11.049
DUOX1 down -4.436 up 7.943
DUS1L up 2.121 down -17.058
DUSP2 down -5.265 up 3.216
DUSP5 down -2.049 up 10.431
EDIL3 down -2.289 up 12.257
EDN3 down -3.244 up 15.114
EDNRA down -2.492 up 8.354
EDNRB down -2.994 up 16.119
EFCAB1 down -2.016 up 2.842
EFEMP1 down -2.582 up 4.426
EFHD1 down -2.38 up 14.155
EFNB1 down -2.434 up 10.012
EGF up 2.011 down -2.139
EGLN3 down -2.159 up 4.496
EHD2 down -2.196 up 8.245
ELAVL3 down -2.626 up 17.071
EN2 up 5.967 down -8.313
EPCAM up 2.156 down -13.106
EPHB1 down -4.249 up 7.13
ERCC6L up 2.257 down -7.86
ESPL1 up 2.483 down -2.712
ESRP2 up 2.204 down -5.597
ETNK2 down -2.388 up 8.113
ETV5 down -2.138 up 9.193
EXO1 up 2.473 down -8.024
EYA4 down -3.284 up 5.473
EZH2 up 2.758 down -6.996
F12 up 3.812 down -7.872
F5 up 2.814 down -5.502
FADS2 down -2.806 up 3.627
FAM107A down -3.006 up 7.655
FAM64A up 2.906 down -12.376
FASN up 2.622 down -11.957
FAT4 down -2.253 up 10.235
FAXDC2 down -2.667 up 9.718
FCGBP down -3.891 up 6.761
FCGR3B down -3.268 up 7.16
FERMT2 down -2.509 up 4.726
FFAR2 up 3.452 down -13.299
FGF7 down -2.718 up 4.639
FHL1 down -2.814 up 8.961
FLRT3 down -2.456 up 14.649
FN1 down -3.23 up 6.412
FOLH1B up 3.73 down -8.885
FOLR1 down -4.848 up 3.02
FOXD1 up 11.748 down -8.249
FOXF1 down -2.117 up 15.378
FOXF2 down -2.243 up 13.708
FOXM1 up 2.832 down -15.111
FUT6 down -5.024 up 4.02
FXYD6 down -3.097 up 9.341
G0S2 down -4.894 up 3.676
GAD1 up 2.262 down -12.176
GALNT6 down -2.213 up 9.875
GAS1 down -2.365 up 8.738
GATM down -2.688 up 5.539
GCNT3 down -2.667 up 6.538
GCNT4 down -5.404 up 3.752
GIPC2 down -2.348 up 7.244
GJA1 down -2.464 up 10.856
GJB4 down -4.335 up 2.794
GNAO1 down -5.666 up 14.239
GNAZ down -3.468 up 14.778
GNG11 down -2.05 up 6.017
GOLM1 up 3.394 down -8.443
GPD1 down -5.293 up 18.972
GPM6A down -3.135 up 14.354
GPM6B down -2.255 up 7.146
GPR161 down -2.374 up 5.953
GPR75 down -2.048 up 2.087
GPRASP1 down -2.141 up 2.042
GPX3 down -2.147 up 8.59
GRM4 up 2.445 down -3.72
GSTM2 down -2.366 up 3.288
GSTM3 down -4.911 up 2.75
GSTP1 down -4.174 up 8.872
GTSE1 up 3.823 down -12.521
HAAO down -2.07 up 2.662
HAND2 down -2.175 up 7.441
HAPLN2 down -2.008 up 11.492
HECW1 down -2.545 up 4.351
HEPH down -2.339 up 6.979
HEY2 up 2.215 down -3.179
HIF3A down -2.956 up 11.57
HIST1H2BG up 2.578 down -4.743
HJURP up 4.179 down -8.792
HLA-DMB up 3.346 down -5.57
HLF down -2.26 up 4.276
HMMR up 2.654 down -12.228
HOXB3 down -3.076 up 3.281
HOXC6 up 7.748 down -10.887
HOXD13 down -3.449 up 2.283
HOXD3 down -2.756 up 3.294
HPD down -2.811 up 6.381
HPN up 5.672 down -9.963
HR down -2.099 up 8.598
HRH2 down -2.616 up 14.262
HSD11B1 down -2.571 up 14.361
HSD17B2 down -2.135 up 8.679
HSF4 up 3 down -3.086
HSPA1A down -2.031 up 8.795
HSPA4L down -2.691 up 9.248
HSPA6 down -11.835 up 6.613
HSPB8 down -3.578 up 2.046
HUNK down -2.442 up 9.703
ID1 down -2.773 up 2.916
ID3 down -2.335 up 9.468
IER3 down -3.242 up 10.015
IL1RL1 down -4.471 up 12.973
IL1RL2 down -2.431 up 9.429
IL33 down -2.155 up 11.472
INSM1 up 3.068 down -2.434
IQCA1 down -2.536 up 4.146
IQSEC3 down -2.707 up 14.186
IRF5 down -2.625 up 5.465
IRX4 up 2.39 down -8.175
ITGA2 down -2.517 up 4.423
ITGA5 down -2.218 up 3.22
ITGA8 down -2.039 up 13.904
ITGB3 down -2.709 up 5.589
ITGB6 down -2.841 up 4.317
ITGBL1 up 2.995 down -11.375
ITIH5 down -2.304 up 13.679
JAKMIP2 down -2.283 up 13.723
JPH2 down -2.694 up 5.25
KAT2A up 2.026 down -17.062
KCNAB1 down -2.876 up 4.928
KCNB1 down -2.389 up 4.185
KCNH1 down -2.363 up 2.821
KCNJ3 down -3.863 up 3.003
KCNJ5 down -8.76 up 12.379
KCNJ8 down -2.293 up 8.31
KCNK15 down -2.117 up 2.041
KCNK3 down -2.143 up 4.15
KCNMA1 down -2.601 up 3.839
KCNQ1 down -3.739 up 6.458
KIAA0101 up 2.064 down -8.227
KIAA1644 down -2.677 up 4.025
KIF14 up 2.605 down -3.653
KIF18B up 3.877 down -10.914
KIF20A up 2.927 down -18.527
KIF26B down -2.846 up 12.174
KIF4A up 3.416 down -6.77
KIFC1 up 2.651 down -12.359
KRT16 down -5.347 up 8.891
KRT4 down -4.422 up 6.613
KSR1 down -2.25 up 2.81
L1CAM down -2.405 up 9.185
LARGE down -2.276 up 7.617
LDB3 down -3.125 up 6.49
LGALS4 down -3.287 up 11.573
LIMS2 down -2.208 up 10.462
LINC00115 up 2.295 down -4.31
LIPG down -7.103 up 6.356
LMOD1 down -3.082 up 2.936
LPAR1 down -2.219 up 4.009
LRMP down -2.332 up 4.124
LRP1B down -3.172 up 8.846
LRRC17 down -2.293 up 5.647
LRRC31 up 2.24 down -6.824
LRRN3 down -2.838 up 10.752
LSAMP down -2.57 up 17.988
LYVE1 down -4.831 up 7.059
MAP1A down -2.882 up 15.586
MAP1B down -2.31 up 2.942
MASP1 down -2.625 up 13.899
MATK up 5.983 down -6.636
MBNL2 down -2.089 up 23.331
MCAM down -2.096 up 8.641
MCCC2 up 2.393 down -18.891
MCM10 up 2.055 down -5.293
ME1 down -3.542 up 5.453
MEIS1 down -2.27 up 6.097
MELK up 3.051 down -9.13
METTL7A down -2.072 up 11.08
MKI67 up 2.849 down -5.855
MMP1 down -2.179 up 66.955
MMP26 up 8.47 down -13.009
MMP9 up 2.966 down -2.363
MNX1 up 4.631 down -6.029
MON1B up 2.942 down -8.736
MRPL12 up 2.05 down -2.266
MTG1 up 2.037 down -8.75
MXRA7 down -2.314 up 7.121
MYH3 down -2.159 up 8.316
MYL9 down -2.507 up 2.074
NAV2 down -2.634 up 5.349
NCAM1 down -3.299 up 8.279
NCAPG up 3.312 down -13.65
NCAPH up 2.716 down -8.155
NCS1 down -2.274 up 7.786
NDNF down -2.469 up 7.442
NDRG4 down -10.301 up 9.054
NEFM down -7.456 up 6.186
NETO2 up 4.202 down -21.96
NFE2L3 up 2.076 down -4.359
NLGN3 down -2.352 up 12.972
NMUR1 down -2.514 up 6.282
NOS1 down -2.864 up 2.571
NOX1 down -3.087 up 2.235
NPR2 down -2.07 up 9.779
NPY6R down -4.608 up 4.143
NR4A3 down -2.395 up 11.024
NRCAM down -2.434 up 9.644
NRG1 down -2.421 up 2.325
NRXN1 down -2.738 up 5.641
NSG1 down -3.033 up 14.235
NT5E down -2.429 up 2.117
NTF3 down -2.15 up 3.393
NTRK1 down -2.225 up 13.076
NUP210 up 2.35 down -4.208
NXPE4 down -3.909 up 3.369
NYNRIN down -3.769 up 7.535
OLFM4 down -4.046 up 6.194
OR51E2 up 5.291 down -2.478
ORC6 up 2.074 down -7.049
P2RX1 down -2.887 up 17.849
P2RX2 down -3.554 up 4.859
P2RX6 down -2.949 up 4.11
PALLD down -2.79 up 14.694
PAQR5 down -3.196 up 3.921
PARM1 down -2.154 up 3.571
PBK up 2.835 down -7.132
PCDH7 down -3.715 up 3.745
PCDH9 down -2.384 up 2.363
PCSK6 up 3.061 down -2.315
PDE7B down -3.187 up 6.307
PDK4 down -8.221 up 10.777
PDLIM5 up 3.023 down -3.998
PDPN down -2.016 up 15.447
PEG10 down -2.098 up 8.104
PEG3 down -2.202 up 5.556
PEX10 up 2.516 down -6.682
PFKFB3 down -2.11 up 6.013
PGF down -2.691 up 9.369
PGM5 down -3.36 up 2.174
PIK3R1 down -2.003 up 2.967
PINLYP down -2.108 up 5.027
PIP5K1B down -3.397 up 11.735
PIPOX down -2.314 up 8.294
PITPNM3 down -2.035 up 2.784
PKMYT1 up 2.53 down -2.829
PLA2G2D up 2.474 down -3.94
PLA2G4A down -5.027 up 2.082
PLA2G7 up 3.318 down -2.415
PLCL1 down -3.002 up 2.406
PLK1 up 2.702 down -15.958
PLP1 down -2.771 up 8.468
PLPPR1 up 3.288 down -4.229
PNMA2 down -2.719 up 16.187
PNMT down -25.429 up 7.648
POLQ up 2.247 down -3.556
PPARGC1A down -3.37 up 2.146
PPEF1 up 2.315 down -4.003
PPP1R14B up 2.446 down -3.053
PPP1R3C down -3.14 up 12.965
PPP2R2B down -2.815 up 2.557
PRAME up 7.193 down -3.883
PRDM16 down -6.082 up 3.779
PRDM8 down -3.128 up 10.357
PRKCA down -2.223 up 4.669
PRKCB down -3.439 up 6.375
PRKG1 down -2.99 up 10.086
PRLR down -3.418 up 4.646
PRODH down -2.59 up 10.666
PRPH2 down -2.413 up 3.955
PRR16 up 3.583 down -10.232
PRSS12 down -2.131 up 3.042
PTGS1 down -5.671 up 9.364
PTP4A3 up 2.779 down -2.971
PYCR1 up 2.585 down -3.585
PYGL down -2.293 up 4.09
QPRT down -5.319 up 12.786
QSOX1 down -2.018 up 5.453
RAB26 up 2.415 down -7.823
RAB40A down -2.792 up 3.25
RABEP2 up 2.121 down -12.887
RAD51 up 2.088 down -15.355
RASAL1 down -8.546 up 5.516
RASL12 down -2.97 up 3.369
RBMS3 down -2.548 up 8.817
RBP1 down -2.764 up 21.15
RBP4 down -2.142 up 4.529
RBPMS down -2.098 up 4.4
RCAN2 down -2.144 up 2.631
REC8 down -2.032 up 3.526
RELN up 3.249 down -8.742
RGN down -2.354 up 21.356
RGS11 up 3.354 down -6.237
RGS13 down -2.27 up 13.468
RGS9 down -2.384 up 4.356
RHCG down -4.043 up 9.813
RHOB down -2.075 up 7.25
RHOBTB2 down -2.396 up 4.518
RIMS3 down -2.375 up 13.486
RNASE1 down -2.276 up 8.918
RND2 down -2.758 up 20.27
RND3 down -2.315 up 2.667
RPE65 down -4.588 up 8.21
RPL36A up 2.13 down -5.699
RRM2 up 4.032 down -12.404
RSPH14 down -2.926 up 4.99
S100A14 down -4.3 up 16.322
S100A6 down -2.142 up 2.429
S100A8 down -2.098 up 4.288
S100B down -2.473 up 3.553
S1PR5 down -2.312 up 2.574
SCARA3 down -3.363 up 6.068
SCGB1A1 down -5.573 up 6.107
SCN2B down -3.095 up 19.609
SCN4A down -2.031 up 7.717
SCN5A down -3.402 up 8.006
SCN7A down -2.249 up 5.71
SCRG1 down -2.308 up 4.206
SEC31B up 2.154 down -4.073
SELE down -2.159 up 5.641
SEMA3A down -3.135 up 9.911
SEMA3D down -2.155 up 9.32
SEMA5A down -2.166 up 9.666
SEMA7A down -2.057 up 3.086
SEMG1 down -881.943 up 2.942
SERPINA5 down -111.519 up 9.322
SERPINB1 down -2.22 up 5.309
SFRP5 down -6.876 up 5.362
SGCA down -2.161 up 7.272
SGCB down -2.125 up 3.12
SGCE down -2.085 up 19.306
SGCG down -2.774 up 4.079
SGK1 down -2.173 up 14.216
SHCBP1 up 2.687 down -15.901
SIK1 down -2.421 up 8.617
SIM2 up 4.714 down -17.963
SKA1 up 2.467 down -10.568
SLC14A1 down -3.751 up 16.981
SLC16A7 down -2.017 up 4.06
SLC18A2 down -5.93 up 8.536
SLC19A1 up 2.722 down -28.216
SLC24A3 down -2.258 up 6.239
SLC25A10 up 2.212 down -7.919
SLC26A3 down -26.536 up 10.963
SLC2A4 down -2.309 up 2.281
SLC34A2 down -9.153 up 6.233
SLC52A1 down -2.821 up 2.774
SLC7A11 up 3.074 down -19.189
SLC7A5 down -3.351 up 4.03
SLC8A2 down -2.411 up 3.873
SLCO1B3 up 15.497 down -20.083
SLCO2A1 down -3.363 up 12.108
SLCO3A1 down -2.492 up 4.98
SLFN12 down -2.062 up 3.064
SMS up 2.645 down -3.472
SMTN down -2.304 up 5.088
SNAI2 down -2.87 up 11.772
SNCG down -3.109 up 5.222
SNHG3 up 3.009 down -3.167
SNPH down -3.531 up 4.467
SNX7 down -2.112 up 4.889
SORBS1 down -2.891 up 2.179
SOSTDC1 down -3.713 up 3.617
SOX15 down -2.617 up 7.841
SPAG5 up 2.261 down -6.559
SPARCL1 down -2.155 up 3.815
SPC25 up 2.813 down -14.224
SPEG down -2.193 up 5.961
SPOCK3 down -3.064 up 6.056
SPON1 down -3.019 up 9.575
SSPN down -2.127 up 4.048
SST down -3.852 up 15.361
ST6GALNAC4 down -3.498 up 8.597
STAC down -5.261 up 6.35
STARD8 down -2.331 up 5.218
STIL up 2.211 down -5.77
SYNC down -2.474 up 5.907
SYNM down -3.472 up 5.363
TACC1 down -2.026 up 15.297
TAGLN down -2.549 up 11.122
TBX4 down -4.529 up 9.535
TBX5 down -3.239 up 5.01
TCEAL2 down -2.638 up 9.398
TCF7L1 down -2.304 up 2.01
TDO2 up 4.344 down -3.345
TENM1 up 3.604 down -5.487
TENM3 down -2.323 up 11.582
TES down -2.215 up 4.215
TFF3 up 9.702 down -3.276
TGFB3 down -2.252 up 2.137
TGM1 down -2.493 up 10.08
THBS4 up 3.014 down -14.96
TIMP3 down -2.655 up 9.383
TLR2 down -2.728 up 5.898
TMC5 up 2.315 down -5.363
TMEM100 down -3.594 up 4.879
TMEM158 down -2.159 up 6.269
TMEM35 down -3.796 up 4.985
TMEM40 down -3.356 up 11.232
TMOD1 down -2.061 up 15.87
TNN up 4.942 down -8.632
TNS1 down -2.71 up 8.233
TOP2A up 2.53 down -19.841
TP53AIP1 down -2.689 up 7.792
TPM2 down -2.214 up 2.349
TPX2 up 2.876 down -20.267
TRHDE down -3.201 up 5.454
TRIB3 up 2.035 down -15.434
TRIP13 up 2.313 down -21.139
TROAP up 3.545 down -6.612
TRPC1 down -2.125 up 2.16
TRPC4 down -2.236 up 6.855
TRPC6 down -2.787 up 7.552
TSPAN1 up 2.384 down -3.454
TSPAN2 down -2.24 up 2.813
TTK up 2.302 down -14.894
TYRP1 up 2.721 down -2.581
UBE2C up 3.217 down -30.451
UNC5B down -4.668 up 6.519
VCL down -2.616 up 3.966
VGLL1 down -2.912 up 7.328
VWA5A down -2.347 up 14.334
WFDC1 down -2.272 up 12.959
WISP2 down -3.071 up 9.507
WNT16 down -2.353 up 5.08
WWC3 down -2.626 up 13.2
YBX2 down -2.02 up 14.05
ZEB2 down -2.083 up 3.349
ZFPM2 down -2.197 up 7.511
ZNF185 down -4.044 up 2.721
ZNF692 up 2.173 down -9.52
ZNF750 down -3.112 up 6.315
Enrichment Result
GO
PID
KEGG
REACTOME
Pathway Name P-value Reverse Num Hit Num Gene List
Genes Fold change of
cancer samples vs. normal samples 		Fold change of
compound treated vs. DMSO treated cell lines
ADGRF5 up 2.386 up 19.14
ADORA2B down -2.039 down -21.56
ALDH3A1 down -2.898 down -26.043
BEX1 down -2.012 down -17.152
CACNB1 0 0 up 15.924
CYP24A1 down -2.234 down -20.861
DKK1 down -2.822 down -15.359
DUSP4 down -3.431 down -79.899
DYNC1I1 down -2.304 down -15.362
FOSL1 down -3.064 down -99.134
GBA3 0 0 up 15.595
GPR37 up 2.41 up 17.717
GPR37L1 0 0 up 15.286
GPX2 down -5.766 down -16.695
HIST1H1C up 2.121 up 17.409
HIST1H2AI up 2.789 up 19.763
HOXA7 down -2.359 down -16.104
IFI6 up 2.815 up 24.207
IL11 up 2.548 up 22.103
ISG15 up 3.999 up 18.593
KCNH4 0 0 up 19.889
MECOM down -2.741 down -18.412
MSLN down -6.384 down -15.772
NEAT1 up 2.392 up 17.928
PAOX up 2.019 up 16.315
PLA2G2A up 3.469 up 17.261
POLD4 0 0 up 15.622
PRPS2 down -2.412 down -19.063
SDS up 2.776 up 20.881
SGSM3 0 0 up 17.894
SPINK2 0 0 up 18.652
SYP up 2.024 up 19.583
TBX10 up 6.59 up 15.507
TGFB1I1 down -2.414 down -16.268
TRIM36 up 2.84 up 15.98
TUBB2A up 2.595 up 20.616
TUBB4A up 7.899 up 19.221
ULBP2 up 2.895 up 28.771
VGF up 5.693 up 17.484
Enrichment Result
GO
PID
KEGG
REACTOME
Pathway Name P-value Adverse num Hit num Gene List

reverse gene
Genes Fold change of
cancer samples vs. normal samples 		Fold change of
compound treated vs. DMSO treated cell lines
adverse gene
Genes Fold change of
cancer samples vs. normal samples 		Fold change of
compound treated vs. DMSO treated cell lines