DataBase of Pharmaco-omics for Cancer Precision Medicine
Compound Detail
Differential gene expression analyses have been performed on both
cancer vs. control tissues samples (E1) from TCGA and molecular compound treated cell line vs.
DMSO treated cell line (E2) from the CMap database.
When a cell line is treated with a compound,
if the effect on a gene is opposite, i.e., one up-regulated or 1 in E1 and the other
down-regulated or -1 in E2, or conversely, we consider it having a reversed effect on this gene.
Otherwise, if a gene is marked as 1(E1) ~1(E2), -1(E1) ~-1(E2), 0(E1) ~1(E2) or 0(E1) ~-1(E2)
with 0 for no change, we consider that the compound has an adverse effect on this gene.
geldanamycin
ID: BRD-A19500257 | Dosage: 1 µM | Time: 6 h
| Genes | Fold change of cancer samples vs. normal samples |
Fold change of compound treated vs. DMSO treated cell lines |
|---|---|---|
| ADAM2 | up 13.118 | down -4.351 |
| ADGRF5 | up 2.386 | down -5.444 |
| ADGRG2 | down -2.288 | up 8.356 |
| ADGRG6 | down -2.458 | up 3.539 |
| ADGRV1 | up 2.147 | down -2.722 |
| ADM2 | up 2.445 | down -2.308 |
| ADRA2A | up 2.632 | down -7.75 |
| ADRB1 | up 2.071 | down -4.161 |
| AK5 | up 4.007 | down -3.166 |
| AKR1B1 | down -14.798 | up 2.758 |
| AKR1C2 | down -2.254 | up 3.533 |
| ALDH1A3 | up 2.044 | down -5.303 |
| ALDH3A1 | down -2.898 | up 3.891 |
| AMH | up 9.429 | down -4.626 |
| ANP32E | down -2.191 | up 6.422 |
| ANXA6 | down -2.24 | up 5.884 |
| AOX1 | down -5.345 | up 2.085 |
| APBA2 | up 2.258 | down -2.983 |
| APOBEC3F | down -2.145 | up 3.117 |
| APOC1 | up 4.942 | down -2.475 |
| AQP5 | down -4.608 | up 3.976 |
| AQP9 | down -2.503 | up 2.901 |
| ARHGDIG | up 6.589 | down -2.406 |
| ARHGEF38 | up 2.933 | down -3.304 |
| ARL4D | down -3.486 | up 4.314 |
| ASF1B | up 2.275 | down -10.129 |
| ASIC2 | up 3.084 | down -2.701 |
| ASIC3 | up 3.037 | down -3.799 |
| ASMTL-AS1 | up 3.135 | down -2.35 |
| ASPM | up 2.616 | down -2.426 |
| ATP8A2 | up 11.657 | down -2.291 |
| AURKB | up 2.903 | down -9.237 |
| AVPI1 | down -2.224 | up 9.169 |
| B3GAT1 | up 3.217 | down -2.688 |
| BCAM | up 2.029 | down -3.904 |
| BCHE | down -3.471 | up 3.867 |
| BEAN1 | up 2.074 | down -2.968 |
| BEX1 | down -2.012 | up 3.919 |
| BIK | up 2.214 | down -2.453 |
| BIRC5 | up 3.842 | down -3.456 |
| BRSK2 | up 5.035 | down -3.14 |
| BUB1 | up 2.573 | down -5.56 |
| BUB1B | up 2.785 | down -2.53 |
| C16orf45 | down -2.356 | up 4.593 |
| C16orf59 | up 2.728 | down -4.017 |
| C2orf72 | up 5.08 | down -6.959 |
| CA10 | up 2.531 | down -5.202 |
| CAMK2A | down -2.859 | up 3.672 |
| CAMKK2 | up 3.176 | down -5.065 |
| CAP2 | down -2.139 | up 5.05 |
| CAPG | down -2.324 | up 2.24 |
| CAPN6 | down -4.558 | up 7.376 |
| CASC5 | up 2.045 | down -3.345 |
| CBX2 | up 2.779 | down -2.93 |
| CCKBR | down -2.508 | up 2.321 |
| CDC20 | up 3.778 | down -2.499 |
| CDC25C | up 3.537 | down -3.908 |
| CDC45 | up 2.585 | down -5.999 |
| CDCA3 | up 2.387 | down -3.508 |
| CDH22 | down -2.091 | up 3.093 |
| CDH7 | up 2.153 | down -3.652 |
| CDK5R1 | up 2.238 | down -2.472 |
| CEACAM5 | up 2.226 | down -2.584 |
| CEACAM6 | down -2.848 | up 2.593 |
| CELSR3 | up 3.383 | down -2.088 |
| CENPF | up 2.966 | down -2.925 |
| CENPU | up 2.058 | down -9.75 |
| CEP55 | up 2.489 | down -2.204 |
| CERS4 | up 2.051 | down -4.9 |
| CES3 | up 2.248 | down -4.977 |
| CHIT1 | up 4.328 | down -6.32 |
| CHRNA1 | up 2.49 | down -3.129 |
| CLDN1 | down -2.048 | up 9.375 |
| CLDN3 | up 2.203 | down -5.082 |
| CLIP4 | down -2.218 | up 3.225 |
| CLU | down -6.008 | up 4.234 |
| COL9A2 | up 4.77 | down -7.099 |
| COLEC12 | up 2.264 | down -2.801 |
| CPB1 | up 2.692 | down -3.434 |
| CPEB1 | down -2.513 | up 4.647 |
| CRYAB | down -2.683 | up 2.743 |
| CRYBA2 | up 3.08 | down -2.464 |
| CSPG5 | up 2.179 | down -8.073 |
| CSRP1 | down -2.737 | up 2.865 |
| CST1 | up 4.695 | down -6.083 |
| CTNND2 | up 2.228 | down -6.81 |
| CTSE | down -2.05 | up 3.773 |
| CXCL10 | up 2.02 | down -7.504 |
| CXCL11 | up 2.51 | down -4.839 |
| CXCL14 | up 2.346 | down -2.332 |
| CXCL9 | up 2.021 | down -3.036 |
| CXCR2 | down -6.188 | up 4.241 |
| CYP2J2 | up 2.722 | down -6.031 |
| CYP2W1 | down -2.416 | up 2.52 |
| CYP4B1 | down -4.508 | up 2.139 |
| CYP4F3 | down -3.706 | up 8.585 |
| DCN | down -2.041 | up 3.438 |
| DCSTAMP | up 3.052 | down -6.358 |
| DDC | up 3.596 | down -2.302 |
| DDIT4 | down -2.291 | up 3.995 |
| DDR2 | down -2.293 | up 2.751 |
| DEFB1 | down -2.284 | up 7.474 |
| DIAPH3 | up 2.023 | down -2.023 |
| DKK1 | down -2.822 | up 2.424 |
| DLX2 | up 9.489 | down -4.615 |
| DMBT1 | down -4.804 | up 5.114 |
| DNAJB1 | down -2.269 | up 8.744 |
| DNAJB4 | down -2.421 | up 11.389 |
| DUOX1 | down -4.436 | up 2.926 |
| ECEL1 | up 2.153 | down -2.603 |
| EFEMP1 | down -2.582 | up 3.561 |
| ELAVL2 | up 4.871 | down -3.599 |
| ELF5 | down -3.573 | up 3.922 |
| EN2 | up 5.967 | down -4.782 |
| ENTPD3 | down -2.573 | up 6.488 |
| ENTPD5 | up 2.322 | down -3.469 |
| EPCAM | up 2.156 | down -2.707 |
| ERCC6L | up 2.257 | down -2.672 |
| ERN2 | down -3.075 | up 4.633 |
| ESPL1 | up 2.483 | down -2.42 |
| ESRP2 | up 2.204 | down -4.346 |
| EXO1 | up 2.473 | down -5.432 |
| EZH2 | up 2.758 | down -14.374 |
| F2RL2 | up 4.235 | down -3.864 |
| FABP5 | up 8.342 | down -3.572 |
| FADS2 | down -2.806 | up 3.09 |
| FAM189A1 | up 2.318 | down -6.211 |
| FAM46A | down -2.39 | up 7.651 |
| FBXL8 | up 2.264 | down -3.002 |
| FCGR3B | down -3.268 | up 4.464 |
| FLNA | down -2.799 | up 4.46 |
| FOXD3 | up 2.284 | down -2.897 |
| FOXM1 | up 2.832 | down -3.277 |
| FSCN2 | up 2.054 | down -2.198 |
| FUT2 | down -3.224 | up 3.433 |
| GABRB3 | up 2.669 | down -2.773 |
| GAD1 | up 2.262 | down -3.715 |
| GAL | up 5.298 | down -3.71 |
| GAS1 | down -2.365 | up 5.556 |
| GJA3 | up 4.081 | down -3.774 |
| GNAL | down -2.69 | up 2.381 |
| GNMT | up 2.118 | down -2.22 |
| GPR37 | up 2.41 | down -7.225 |
| GPRC5D | up 2.091 | down -2.214 |
| GPX2 | down -5.766 | up 5.5 |
| GPX3 | down -2.147 | up 2.427 |
| GRAMD1B | down -3.823 | up 3.943 |
| GRPR | up 4.19 | down -3.45 |
| GSTP1 | down -4.174 | up 6.454 |
| H2AFJ | up 2.223 | down -2.248 |
| HBB | down -3.356 | up 4.853 |
| HCN2 | up 2.81 | down -3.473 |
| HEY2 | up 2.215 | down -5.133 |
| HHIPL2 | down -2.318 | up 5.2 |
| HIST1H1E | up 4.606 | down -6.117 |
| HIST1H2AI | up 2.789 | down -4.847 |
| HIST1H2BN | up 2.205 | down -6.19 |
| HOXB2 | down -3.272 | up 2.694 |
| HOXB6 | down -24.413 | up 2.636 |
| HOXC4 | up 4.98 | down -5.238 |
| HPD | down -2.811 | up 3.532 |
| HRH3 | up 2.254 | down -3.416 |
| HSPA1A | down -2.031 | up 10.576 |
| HSPA4L | down -2.691 | up 12.448 |
| HSPA6 | down -11.835 | up 17.463 |
| HSPB8 | down -3.578 | up 6.29 |
| IGF2BP2 | down -2.052 | up 7.156 |
| IL11 | up 2.548 | down -2.788 |
| IL1RAPL1 | up 2.98 | down -3.447 |
| INHA | up 2.205 | down -2.748 |
| INSL5 | up 2.728 | down -5.05 |
| INSM1 | up 3.068 | down -3.542 |
| ITPR1 | down -2.315 | up 2.395 |
| IZUMO4 | up 2.159 | down -5.01 |
| KCNMB2 | up 2.613 | down -2.761 |
| KCNS1 | down -6.79 | up 8.236 |
| KIF18B | up 3.877 | down -3.049 |
| KIF20A | up 2.927 | down -3.661 |
| KIF25 | up 4.07 | down -8.377 |
| KIFC1 | up 2.651 | down -4.498 |
| KLK12 | up 5.564 | down -2.481 |
| KLK14 | up 4.47 | down -5.452 |
| KLK15 | up 4.129 | down -5.322 |
| KRT23 | down -3.172 | up 4.938 |
| LFNG | up 2.18 | down -2.482 |
| LIMS2 | down -2.208 | up 3.231 |
| LINC00115 | up 2.295 | down -3.459 |
| LINC00939 | up 5.999 | down -2.74 |
| LIPG | down -7.103 | up 2.508 |
| LMX1B | up 7.413 | down -3.564 |
| LRRC31 | up 2.24 | down -3.605 |
| LUZP2 | up 3.728 | down -6.04 |
| LY6D | down -9.507 | up 3.201 |
| MAP1A | down -2.882 | up 5.78 |
| MARCKSL1 | up 2.625 | down -2.863 |
| MBNL2 | down -2.089 | up 15.846 |
| MCCC2 | up 2.393 | down -3.527 |
| MCM10 | up 2.055 | down -2.348 |
| ME1 | down -3.542 | up 3.903 |
| MELK | up 3.051 | down -3.767 |
| MIPEP | up 3.244 | down -11.961 |
| MMP10 | up 2.238 | down -4.466 |
| MNX1 | up 4.631 | down -3.495 |
| MR1 | down -2.228 | up 2.014 |
| MSI1 | up 2.126 | down -7.943 |
| MUC13 | up 2.637 | down -4.198 |
| MUC2 | up 2.273 | down -2.124 |
| MUC4 | down -3.413 | up 3.206 |
| MUC6 | down -31.227 | up 4.54 |
| MXD3 | up 2.657 | down -5.038 |
| MYBL2 | up 5.134 | down -9.792 |
| MYL5 | up 2.169 | down -6.815 |
| MYRIP | up 2.031 | down -7.486 |
| MYT1 | up 3.74 | down -6.835 |
| NCAPG | up 3.312 | down -5.022 |
| NCAPH | up 2.716 | down -4.218 |
| NDRG2 | down -2.479 | up 5.685 |
| NEK2 | up 3.063 | down -4.474 |
| NFE2L3 | up 2.076 | down -3.273 |
| NKAIN1 | up 4.774 | down -4.366 |
| NOL4 | up 4.13 | down -4.848 |
| NOX4 | up 4.014 | down -3.631 |
| NSG1 | down -3.033 | up 2.031 |
| NTRK3 | down -2.162 | up 4.656 |
| ODAM | down -2.196 | up 3.126 |
| OR51E2 | up 5.291 | down -3.094 |
| PALLD | down -2.79 | up 2.25 |
| PAOX | up 2.019 | down -3.431 |
| PAX1 | up 24.788 | down -2.22 |
| PCDHA10 | up 2.578 | down -2.605 |
| PCDHA2 | up 2.927 | down -3.397 |
| PCDHA6 | up 2.339 | down -3.626 |
| PCDHB3 | up 2.124 | down -3.59 |
| PCDHB8 | up 3.7 | down -4.227 |
| PCDHGA1 | up 2.625 | down -3.826 |
| PCSK2 | down -2.812 | up 4.775 |
| PEAK1 | down -2.29 | up 8.131 |
| PEG3 | down -2.202 | up 4.317 |
| PENK | down -4.494 | up 9.328 |
| PGC | down -3.522 | up 8.947 |
| PHYHIP | down -2.441 | up 2.697 |
| PIK3R1 | down -2.003 | up 2.908 |
| PINLYP | down -2.108 | up 5.204 |
| PIPOX | down -2.314 | up 4.484 |
| PLA2G2D | up 2.474 | down -4.308 |
| PLA2G7 | up 3.318 | down -2.473 |
| PLPPR1 | up 3.288 | down -4.628 |
| POTEKP | up 2.017 | down -7.139 |
| POU5F1B | up 2.958 | down -3.312 |
| PPFIA2 | up 5.649 | down -5.452 |
| PPM1E | up 2.382 | down -5.169 |
| PRDM8 | down -3.128 | up 3.01 |
| PRKCB | down -3.439 | up 3.372 |
| PRR16 | up 3.583 | down -5.654 |
| PRR36 | up 3.443 | down -3.408 |
| PRRG4 | down -2.223 | up 5.269 |
| PTGES | down -8.313 | up 3.722 |
| PVT1 | up 2.354 | down -2.837 |
| QPRT | down -5.319 | up 9.481 |
| QSOX1 | down -2.018 | up 4.548 |
| RAB3B | up 2.057 | down -2.373 |
| RAC3 | up 2.52 | down -4.151 |
| RAD51 | up 2.088 | down -5.52 |
| RBFOX1 | down -3.152 | up 2.975 |
| RGN | down -2.354 | up 3.438 |
| RHCG | down -4.043 | up 3.561 |
| ROBO1 | down -2.201 | up 3.344 |
| RPGRIP1 | up 2.168 | down -5.406 |
| RRM2 | up 4.032 | down -2.589 |
| SCGB1A1 | down -5.573 | up 4.959 |
| SCGB2A1 | down -2.706 | up 2.546 |
| SCIN | up 2.084 | down -3.886 |
| SCNN1D | up 2.537 | down -3.46 |
| SEC14L5 | up 2.091 | down -3.499 |
| SEC31B | up 2.154 | down -6.213 |
| SERPINB3 | down -2.339 | up 3.949 |
| SFRP5 | down -6.876 | up 4.35 |
| SIK1 | down -2.421 | up 4.217 |
| SIX2 | down -2.466 | up 5.296 |
| SKA1 | up 2.467 | down -2.506 |
| SKAP1 | down -2.119 | up 4.71 |
| SLC16A4 | down -2.138 | up 4.447 |
| SLC16A7 | down -2.017 | up 3.696 |
| SLC25A10 | up 2.212 | down -5.533 |
| SLC25A22 | up 2.103 | down -5.393 |
| SLC26A1 | up 2.151 | down -2.836 |
| SLC26A6 | up 2.54 | down -3.318 |
| SLC4A10 | up 2.043 | down -2.939 |
| SLC6A11 | up 3.096 | down -2.166 |
| SLC6A3 | up 3.52 | down -4.166 |
| SLC9A3 | up 2.786 | down -5.148 |
| SLCO1A2 | up 9.226 | down -2.672 |
| SLCO1B3 | up 15.497 | down -2.662 |
| SLIT1 | up 7.824 | down -4.975 |
| SLPI | down -11.983 | up 8.049 |
| SMPDL3B | up 3.23 | down -6.028 |
| SMS | up 2.645 | down -2.628 |
| SNHG3 | up 3.009 | down -4.781 |
| SOX14 | up 3.726 | down -4.384 |
| SPAG5 | up 2.261 | down -3.748 |
| SPC25 | up 2.813 | down -5.861 |
| SSTR1 | up 4.107 | down -5.174 |
| ST18 | up 2.526 | down -4.264 |
| ST6GALNAC4 | down -3.498 | up 4.483 |
| SULT1C2 | up 2.309 | down -4.927 |
| SYCE1L | up 3.497 | down -2.193 |
| TAGLN | down -2.549 | up 2.306 |
| TBX1 | up 3.257 | down -6.988 |
| TBX10 | up 6.59 | down -2.101 |
| TENM1 | up 3.604 | down -2.179 |
| TES | down -2.215 | up 3.822 |
| TK1 | up 2.393 | down -9.896 |
| TMEM132A | up 3.237 | down -6.275 |
| TMSB15A | up 2.782 | down -3.371 |
| TNN | up 4.942 | down -2.993 |
| TOP2A | up 2.53 | down -5.368 |
| TOX3 | up 2.101 | down -6.9 |
| TPM1 | down -2.684 | up 4.209 |
| TPO | up 3.419 | down -3.322 |
| TRIB1 | up 2.678 | down -3.352 |
| TRIM29 | down -3.022 | up 4.141 |
| TRIM36 | up 2.84 | down -6.787 |
| TRIP13 | up 2.313 | down -7.135 |
| TROAP | up 3.545 | down -2.873 |
| TRPM8 | up 2.395 | down -5.784 |
| TWIST1 | up 4.473 | down -2.056 |
| VAX2 | up 2.997 | down -3.186 |
| WFDC2 | down -4.909 | up 6.198 |
| YPEL1 | up 2.463 | down -6.944 |
| ZNF516 | down -2.426 | up 5.025 |
| Genes | Fold change of cancer samples vs. normal samples |
Fold change of compound treated vs. DMSO treated cell lines |
|---|---|---|
| FOSL1 | down -3.064 | down -24.169 |
| IER3 | down -3.242 | down -15.106 |
| reverse gene |
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| adverse gene |
|