Differential gene expression analyses have been performed on both
cancer vs. control tissues samples (E1) from TCGA and molecular compound treated cell line vs.
DMSO treated cell line (E2) from the CMap database.
When a cell line is treated with a compound,
if the effect on a gene is opposite, i.e., one up-regulated or 1 in E1 and the other
down-regulated or -1 in E2, or conversely, we consider it having a reversed effect on this gene.
Otherwise, if a gene is marked as 1(E1) ~1(E2), -1(E1) ~-1(E2), 0(E1) ~1(E2) or 0(E1) ~-1(E2)
with 0 for no change, we consider that the compound has an adverse effect on this gene.
ID: BRD-A03772856 | Dosage: 10 µM | Time: 6 h
Genes | Fold change of cancer samples vs. normal samples |
Fold change of compound treated vs. DMSO treated cell lines |
---|---|---|
ABCD2 | down -2.326 | up 5.243 |
ACOT11 | down -2.268 | up 5.193 |
ACOX2 | down -2.934 | up 3.15 |
ACSL6 | down -32.703 | up 5.405 |
ACSS3 | down -2.319 | up 7.785 |
ADAMTS5 | down -3.533 | up 3.34 |
ADGRA2 | down -2.171 | up 2.243 |
ADGRB3 | down -2.684 | up 3.51 |
ADGRF5 | up 2.386 | down -2.056 |
ADGRL3 | down -2.878 | up 6.168 |
ADRA1A | down -4.085 | up 3.795 |
ADRA1D | down -2.894 | up 3.481 |
ADRA2B | down -2.707 | up 9.748 |
AGMAT | up 2.408 | down -3.011 |
ALDH3A1 | down -2.898 | up 2.398 |
AMOT | down -3.157 | up 4.682 |
ANK2 | down -2.596 | up 13.779 |
ANP32E | down -2.191 | up 10.988 |
ANXA2P2 | down -2.658 | up 5.783 |
ANXA9 | down -3.037 | up 9.285 |
AOX1 | down -5.345 | up 4.173 |
APOBEC3F | down -2.145 | up 22.119 |
APOBR | down -2.243 | up 3.49 |
APOC1 | up 4.942 | down -10.377 |
AQP9 | down -2.503 | up 7.432 |
ARC | down -7.025 | up 7.814 |
AREG | down -3.075 | up 3.334 |
ARHGEF40 | down -2.754 | up 8.307 |
ASF1B | up 2.275 | down -3.546 |
ASPHD1 | up 3.494 | down -7.017 |
ASTN1 | down -3.999 | up 2.452 |
ATOH1 | up 14.971 | down -2.797 |
B3GALT2 | down -2.829 | up 4.765 |
B3GAT1 | up 3.217 | down -2.464 |
BAIAP3 | up 2.12 | down -3.183 |
BCHE | down -3.471 | up 5.696 |
BCO1 | down -2.649 | up 2.78 |
BHMT2 | down -2.79 | up 7.736 |
BRSK2 | up 5.035 | down -6.369 |
BUB1B | up 2.785 | down -2.154 |
C16orf59 | up 2.728 | down -3.157 |
C1orf106 | down -3.12 | up 5.822 |
C21orf62 | down -5.628 | up 9.506 |
C7 | down -2.279 | up 3.472 |
CALD1 | down -2.436 | up 7.04 |
CAMK1D | down -2.032 | up 4.077 |
CAND2 | down -2.117 | up 3.352 |
CAPN6 | down -4.558 | up 13.413 |
CARTPT | down -3.792 | up 4.538 |
CASQ2 | down -2.488 | up 6.009 |
CBX8 | up 2.144 | down -4.92 |
CCDC181 | down -2.409 | up 12.214 |
CCL11 | up 2.044 | down -5.392 |
CCL18 | up 3.907 | down -6.855 |
CCNA2 | up 2.478 | down -5.991 |
CDCA3 | up 2.387 | down -4.156 |
CDH22 | down -2.091 | up 8.15 |
CDHR1 | down -3.743 | up 9.292 |
CDK18 | down -3.385 | up 3.083 |
CDKL2 | down -2.641 | up 6.735 |
CDO1 | down -4.862 | up 11.051 |
CEND1 | down -2.868 | up 3.39 |
CENPA | up 3.755 | down -10.249 |
CENPM | up 3.182 | down -3.336 |
CERS4 | up 2.051 | down -3.203 |
CES3 | up 2.248 | down -3.439 |
CFD | down -2.12 | up 3.41 |
CHAD | down -2.139 | up 2.642 |
CHD5 | down -2.253 | up 7.727 |
CHEK1 | down -3.302 | up 3.591 |
CHRDL1 | down -3.755 | up 10.231 |
CHRNA5 | up 2.075 | down -3.252 |
CLIP3 | down -2.687 | up 5.346 |
CLU | down -6.008 | up 6.99 |
CNR1 | down -2.026 | up 5.971 |
CNTFR | down -3.365 | up 3.035 |
COL17A1 | down -3.719 | up 2.26 |
COL21A1 | down -2.448 | up 14.781 |
COLEC12 | up 2.264 | down -2.093 |
CORO2B | down -2.551 | up 2.894 |
CPB1 | up 2.692 | down -2.844 |
CPED1 | down -2.572 | up 7.22 |
CRTAC1 | down -19.791 | up 12.159 |
CRYAB | down -2.683 | up 11.421 |
CST4 | down -5.083 | up 3.162 |
CTLA4 | up 2.313 | down -8.638 |
CTNNA2 | down -2.519 | up 9.315 |
CXCL10 | up 2.02 | down -6.549 |
CXCL11 | up 2.51 | down -4.935 |
CXCL6 | down -2.063 | up 10.277 |
CXCL9 | up 2.021 | down -6.763 |
CXCR2 | down -6.188 | up 11.232 |
CYP27A1 | down -2.083 | up 7.345 |
CYP2E1 | down -3.585 | up 8.821 |
CYP2W1 | down -2.416 | up 19.826 |
CYP3A5 | down -4.019 | up 10.356 |
CYP4F3 | down -3.706 | up 8.663 |
DCN | down -2.041 | up 12.156 |
DCSTAMP | up 3.052 | down -10.153 |
DDIT4 | down -2.291 | up 4.142 |
DDO | down -2.142 | up 14.287 |
DEFB1 | down -2.284 | up 6.569 |
DES | down -2.76 | up 2.702 |
DGKG | down -2.652 | up 2.522 |
DIXDC1 | down -2.078 | up 7.23 |
DKK3 | down -2.066 | up 9.113 |
DLGAP2 | up 2.232 | down -3.532 |
DLX2 | up 9.489 | down -3.772 |
DMD | down -2.942 | up 10.836 |
DNAJB1 | down -2.269 | up 2.626 |
DNAJB4 | down -2.421 | up 3.896 |
DNASE1L2 | up 2.883 | down -8.097 |
DOK4 | down -2.143 | up 9.847 |
DPT | down -3.173 | up 4.331 |
DPYS | down -2.65 | up 3.253 |
DPYSL3 | down -2.268 | up 3.582 |
DUSP2 | down -5.265 | up 3.07 |
DUSP4 | down -3.431 | up 8.165 |
DYNC1I1 | down -2.304 | up 6.335 |
DZIP1 | down -2.12 | up 11.066 |
E2F2 | up 2.052 | down -4.421 |
EDNRA | down -2.492 | up 6.582 |
EDNRB | down -2.994 | up 6.341 |
EFEMP1 | down -2.582 | up 3.633 |
EFHC2 | down -2.181 | up 3.196 |
ELAVL2 | up 4.871 | down -2.002 |
ELAVL3 | down -2.626 | up 3.629 |
ELF5 | down -3.573 | up 6.96 |
ERBB4 | down -3.729 | up 3.634 |
ERN2 | down -3.075 | up 5.848 |
ESPL1 | up 2.483 | down -3.622 |
EXO1 | up 2.473 | down -5.003 |
EYA1 | down -2.343 | up 4.907 |
EYA4 | down -3.284 | up 5.313 |
FADS2 | down -2.806 | up 7.259 |
FAM46A | down -2.39 | up 7.113 |
FAM64A | up 2.906 | down -4.546 |
FAT2 | down -3.657 | up 2.198 |
FAT4 | down -2.253 | up 10.418 |
FAXDC2 | down -2.667 | up 8.737 |
FCER1A | down -2.035 | up 4.069 |
FEZ1 | down -2.356 | up 2.594 |
FGF2 | down -2.231 | up 6.183 |
FGF7 | down -2.718 | up 9.559 |
FHL1 | down -2.814 | up 5.866 |
FOLR1 | down -4.848 | up 5.306 |
FOXL2 | up 5.186 | down -2.413 |
FUT3 | down -17.439 | up 3.146 |
FUT6 | down -5.024 | up 9.38 |
FXYD6 | down -3.097 | up 2.324 |
G0S2 | down -4.894 | up 2.088 |
GABRB3 | up 2.669 | down -5.283 |
GABRD | up 3.674 | down -5.655 |
GAL | up 5.298 | down -2.808 |
GALNT6 | down -2.213 | up 8.044 |
GAS1 | down -2.365 | up 3.406 |
GATM | down -2.688 | up 4.123 |
GIPC2 | down -2.348 | up 3.368 |
GNMT | up 2.118 | down -4.594 |
GPM6A | down -3.135 | up 12.94 |
GPM6B | down -2.255 | up 3.073 |
GPR37 | up 2.41 | down -9.149 |
GPX2 | down -5.766 | up 4.945 |
GRPR | up 4.19 | down -2.254 |
GSTM5 | down -2.623 | up 8.117 |
HAAO | down -2.07 | up 4.735 |
HAPLN1 | down -2.958 | up 3.159 |
HAS2 | down -2.47 | up 8.558 |
HBB | down -3.356 | up 5.949 |
HEPH | down -2.339 | up 2.219 |
HEY2 | up 2.215 | down -2.014 |
HIF3A | down -2.956 | up 2.127 |
HIST1H1C | up 2.121 | down -10.962 |
HIST1H1E | up 4.606 | down -4.402 |
HJURP | up 4.179 | down -5.042 |
HLF | down -2.26 | up 6.824 |
HOXA7 | down -2.359 | up 16.106 |
HOXB3 | down -3.076 | up 4.623 |
HOXB9 | down -13.626 | up 9.919 |
HOXD3 | down -2.756 | up 4.969 |
HPD | down -2.811 | up 12.156 |
HPGD | up 2.512 | down -13.978 |
HR | down -2.099 | up 9.905 |
HRH2 | down -2.616 | up 9.435 |
HS3ST3A1 | down -2.442 | up 10.966 |
HSD11B1 | down -2.571 | up 5.901 |
HSF4 | up 3 | down -6.227 |
HSPB8 | down -3.578 | up 6.003 |
HUNK | down -2.442 | up 2.901 |
ID1 | down -2.773 | up 2.645 |
ID4 | down -3.099 | up 20.184 |
IER3 | down -3.242 | up 3.629 |
IGF2BP2 | down -2.052 | up 3.656 |
IL1R2 | down -2.195 | up 3.127 |
IL1RAPL1 | up 2.98 | down -12.94 |
IL1RL1 | down -4.471 | up 10.274 |
IL33 | down -2.155 | up 8.797 |
IL5RA | up 3.678 | down -2.334 |
INHA | up 2.205 | down -3.936 |
INSM1 | up 3.068 | down -2.123 |
IRAK3 | down -2.173 | up 6.181 |
IRF5 | down -2.625 | up 5.929 |
ISYNA1 | down -2.375 | up 8.612 |
ITGA2 | down -2.517 | up 7.5 |
ITGB3 | down -2.709 | up 5.831 |
ITGB8 | down -2.373 | up 5.348 |
ITIH5 | down -2.304 | up 2.505 |
KAT2A | up 2.026 | down -2.351 |
KCNJ16 | down -40.317 | up 9.186 |
KCNJ8 | down -2.293 | up 3.821 |
KCNK15 | down -2.117 | up 5.053 |
KCNMA1 | down -2.601 | up 3.928 |
KCNN2 | up 2.159 | down -5.705 |
KCNQ1 | down -3.739 | up 3.589 |
KIF20A | up 2.927 | down -2.86 |
KIF26B | down -2.846 | up 7.878 |
KIF2C | up 2.12 | down -2.363 |
KLK12 | up 5.564 | down -4.595 |
KRT23 | down -3.172 | up 5.122 |
KRT4 | down -4.422 | up 7.36 |
LDB3 | down -3.125 | up 3.834 |
LIPC | down -3.557 | up 9.929 |
LONRF3 | down -2.621 | up 3.965 |
LPA | down -2.714 | up 3.978 |
LRP1B | down -3.172 | up 8.028 |
LRP4 | down -2.159 | up 5.729 |
LRRC17 | down -2.293 | up 11.911 |
LRRN3 | down -2.838 | up 5.075 |
LY6D | down -9.507 | up 9.105 |
MAP1A | down -2.882 | up 6.687 |
MAPK8IP2 | up 2.509 | down -5.988 |
MARCO | down -2.143 | up 5.453 |
MASP1 | down -2.625 | up 4.861 |
MECOM | down -2.741 | up 3.989 |
METTL7A | down -2.072 | up 3.368 |
MFAP5 | down -2.631 | up 7.562 |
MKI67 | up 2.849 | down -4.616 |
MLC1 | down -3.421 | up 2.729 |
MMP10 | up 2.238 | down -7.501 |
MMP11 | up 2.396 | down -11.902 |
MMP9 | up 2.966 | down -2.057 |
MON1B | up 2.942 | down -4.794 |
MPP2 | down -2.729 | up 2.141 |
MR1 | down -2.228 | up 7.031 |
MSLN | down -6.384 | up 8.211 |
MSMB | down -2.145 | up 6.494 |
MTG1 | up 2.037 | down -7.294 |
MUC4 | down -3.413 | up 4.967 |
MUC6 | down -31.227 | up 14.223 |
MXRA7 | down -2.314 | up 2.398 |
MYBL2 | up 5.134 | down -6.37 |
MYH3 | down -2.159 | up 12.065 |
MYH6 | down -5.756 | up 2.648 |
MYL9 | down -2.507 | up 2.798 |
MZB1 | up 2.901 | down -17.18 |
NDRG2 | down -2.479 | up 4.363 |
NDRG4 | down -10.301 | up 4.943 |
NETO2 | up 4.202 | down -5.187 |
NID1 | down -2.073 | up 2.584 |
NKAIN1 | up 4.774 | down -4.611 |
NKX2-2 | up 15.698 | down -2.514 |
NKX3-2 | up 2.084 | down -9.632 |
NLGN3 | down -2.352 | up 4.532 |
NMUR1 | down -2.514 | up 8.673 |
NOX1 | down -3.087 | up 2.229 |
NPR2 | down -2.07 | up 5.882 |
NPY | up 4.921 | down -6.041 |
NR4A3 | down -2.395 | up 13.171 |
NRCAM | down -2.434 | up 2.173 |
NRXN1 | down -2.738 | up 2.213 |
NSUN5P1 | up 2.554 | down -2.469 |
NTF3 | down -2.15 | up 5.072 |
NTRK1 | down -2.225 | up 2.166 |
NTRK2 | down -2.159 | up 7.2 |
ODAM | down -2.196 | up 9.929 |
OGN | down -2.542 | up 6.184 |
OLFM4 | down -4.046 | up 7.577 |
P2RX5 | up 3.103 | down -27.547 |
PAOX | up 2.019 | down -5.205 |
PAX2 | down -17.122 | up 9.06 |
PCBP3 | up 2.171 | down -14.213 |
PCDH9 | down -2.384 | up 2.608 |
PCDHGA1 | up 2.625 | down -3.493 |
PCP4 | down -2.61 | up 3.253 |
PCSK6 | up 3.061 | down -3.9 |
PDZRN4 | down -3.157 | up 2.09 |
PEAK1 | down -2.29 | up 5.68 |
PENK | down -4.494 | up 11.128 |
PGC | down -3.522 | up 4.197 |
PGR | down -2.847 | up 4.748 |
PIK3R1 | down -2.003 | up 4.6 |
PILRB | up 2.36 | down -7.14 |
PIPOX | down -2.314 | up 7.022 |
PITX2 | down -2.772 | up 7.622 |
PKMYT1 | up 2.53 | down -5.178 |
PLA2G2D | up 2.474 | down -2.263 |
PLAG1 | down -3.034 | up 8.998 |
PLBD1 | down -2.854 | up 3.485 |
PLN | down -2.451 | up 4.381 |
PNMA1 | down -2.021 | up 5.609 |
PNMAL1 | down -2.21 | up 2.674 |
POF1B | down -2.151 | up 5.159 |
POLQ | up 2.247 | down -2.427 |
POPDC2 | down -2.73 | up 6.44 |
POU2F3 | down -2.921 | up 4.818 |
POU5F1B | up 2.958 | down -6.401 |
PPARGC1A | down -3.37 | up 9.379 |
PRKG1 | down -2.99 | up 3.246 |
PRR36 | up 3.443 | down -3.781 |
PTGES | down -8.313 | up 3.021 |
PTGIS | down -2.497 | up 4.879 |
PTGS2 | down -8.244 | up 4.732 |
PTPRT | up 2.176 | down -4.488 |
QPRT | down -5.319 | up 5.543 |
RAB40A | down -2.792 | up 5.052 |
RABEP2 | up 2.121 | down -3.438 |
RAPGEFL1 | down -2.64 | up 8.07 |
RBFOX1 | down -3.152 | up 2.641 |
RBMS3 | down -2.548 | up 3.478 |
RBP1 | down -2.764 | up 12.223 |
REEP1 | down -2.242 | up 3.215 |
REXO2 | up 2.042 | down -3.302 |
RGN | down -2.354 | up 5.853 |
RGS10 | up 2.219 | down -15.8 |
RGS13 | down -2.27 | up 3.13 |
RGS9 | down -2.384 | up 2.295 |
RHOB | down -2.075 | up 7.458 |
RND2 | down -2.758 | up 4.175 |
ROPN1B | up 2.925 | down -4.024 |
RPE65 | down -4.588 | up 6.327 |
RPGRIP1 | up 2.168 | down -6.659 |
S100A6 | down -2.142 | up 2.25 |
SALL1 | down -2.4 | up 7.016 |
SBSPON | down -4.87 | up 12.153 |
SCARA3 | down -3.363 | up 6.805 |
SCGB1A1 | down -5.573 | up 9.814 |
SCGB2A1 | down -2.706 | up 6.189 |
SCN5A | down -3.402 | up 8.746 |
SCN7A | down -2.249 | up 2.623 |
SCNN1A | down -2.226 | up 3.396 |
SDPR | down -2.557 | up 9.008 |
SEC14L5 | up 2.091 | down -8.417 |
SEC31B | up 2.154 | down -5.529 |
SEMA3D | down -2.155 | up 7.893 |
SEMA5A | down -2.166 | up 14.828 |
SEMG1 | down -881.943 | up 2.496 |
SEMG2 | down -735.211 | up 7.588 |
SERPINA1 | down -3.037 | up 4.406 |
SERPINA4 | down -3.267 | up 6.745 |
SERPINF2 | down -3.072 | up 7.868 |
SFTPA2 | up 4.066 | down -2.23 |
SGCA | down -2.161 | up 12.959 |
SGCG | down -2.774 | up 11.236 |
SGK1 | down -2.173 | up 7.532 |
SKAP1 | down -2.119 | up 8.857 |
SLC16A4 | down -2.138 | up 16.582 |
SLC16A7 | down -2.017 | up 4.184 |
SLC2A4 | down -2.309 | up 2.477 |
SLC34A2 | down -9.153 | up 6.467 |
SLC7A11 | up 3.074 | down -6.644 |
SLC8A1 | down -2.687 | up 2.085 |
SMPDL3B | up 3.23 | down -2.5 |
SNHG3 | up 3.009 | down -7.025 |
SOSTDC1 | down -3.713 | up 2.78 |
SOX5 | down -2.115 | up 2.467 |
SPOCK3 | down -3.064 | up 3.209 |
STARD8 | down -2.331 | up 5.088 |
SULT4A1 | up 4.99 | down -6.569 |
SV2C | up 2.041 | down -5.122 |
SYNC | down -2.474 | up 6.1 |
TACC1 | down -2.026 | up 2.022 |
TENM3 | down -2.323 | up 3.878 |
TGM4 | down -6.254 | up 3.649 |
TINAGL1 | down -2.295 | up 8.076 |
TK1 | up 2.393 | down -4.968 |
TLR2 | down -2.728 | up 2.687 |
TMEM100 | down -3.594 | up 7.62 |
TMEM132A | up 3.237 | down -8.607 |
TMEM47 | down -2.037 | up 16.82 |
TMOD2 | down -2.07 | up 6.454 |
TMPRSS4 | down -3.584 | up 4.959 |
TMSB15A | up 2.782 | down -5.096 |
TNS4 | down -2.988 | up 14.261 |
TOR4A | down -2.27 | up 2.471 |
TPX2 | up 2.876 | down -3.733 |
TRIB1 | up 2.678 | down -7.717 |
TRIB3 | up 2.035 | down -19.716 |
TRIM31 | down -6.142 | up 4.548 |
TRIM36 | up 2.84 | down -3.951 |
TRIM9 | down -4.708 | up 7.214 |
TRIP13 | up 2.313 | down -9.26 |
TRO | down -2.165 | up 3.509 |
TROAP | up 3.545 | down -3.993 |
TRPC1 | down -2.125 | up 9.871 |
TRPC4 | down -2.236 | up 7.205 |
TRPC6 | down -2.787 | up 2.327 |
TRPM2 | up 2.684 | down -7.774 |
TRPM4 | up 3.331 | down -4.193 |
TTK | up 2.302 | down -2.226 |
TUBB4A | up 7.899 | down -3.146 |
VTN | down -2.937 | up 10.957 |
WFDC2 | down -4.909 | up 4.836 |
ZBTB7C | down -2.545 | up 3.576 |
ZEB2 | down -2.083 | up 9.796 |
ZFHX4 | down -2.275 | up 10.405 |
ZFPM2 | down -2.197 | up 10.877 |
ZNF185 | down -4.044 | up 3.491 |
ZNF692 | up 2.173 | down -6.881 |
Genes | Fold change of cancer samples vs. normal samples |
Fold change of compound treated vs. DMSO treated cell lines |
---|---|---|
ADRA2A | up 2.632 | up 19.481 |
AMACR | up 9.505 | up 25.959 |
ASPH | 0 0 | down -16.696 |
CLDN3 | up 2.203 | up 20.161 |
F7 | 0 0 | up 15.717 |
GJA1 | down -2.464 | down -16.491 |
H2AFJ | up 2.223 | up 16.75 |
IRX4 | up 2.39 | up 15.39 |
ITGBL1 | up 2.995 | up 34.328 |
MYRIP | up 2.031 | up 17.538 |
PRR16 | up 3.583 | up 16.536 |
RASGRF1 | down -2.721 | down -16.185 |
SLC6A11 | up 3.096 | up 22.026 |
TMEM158 | down -2.159 | down -15.998 |
TNFRSF10C | 0 0 | up 18.385 |
WWC3 | down -2.626 | down -16.434 |
reverse gene |
|
|||
adverse gene |
|