Compound Detail

Differential gene expression analyses have been performed on both cancer vs. control tissues samples (E1) from TCGA and molecular compound treated cell line vs. DMSO treated cell line (E2) from the CMap database.
When a cell line is treated with a compound, if the effect on a gene is opposite, i.e., one up-regulated or 1 in E1 and the other down-regulated or -1 in E2, or conversely, we consider it having a reversed effect on this gene. Otherwise, if a gene is marked as 1(E1) ~1(E2), -1(E1) ~-1(E2), 0(E1) ~1(E2) or 0(E1) ~-1(E2) with 0 for no change, we consider that the compound has an adverse effect on this gene.

BRD-A03772856

ID: BRD-A03772856 | Dosage: 1 µM | Time: 6 h

Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines
ABCC3 down -2.485 up 7.235
ABCD2 down -2.326 up 4.843
ABCG2 down -7.091 up 12.473
ABHD6 down -2.564 up 5.922
ABO down -2.498 up 11.402
ACACB down -2.074 up 4.091
ACAN up 2.286 down -4.829
ACE down -2.542 up 2.97
ACE2 down -2.729 up 8.558
ACKR4 down -3.713 up 3.143
ACOT11 down -2.268 up 2.432
ACOX2 down -2.934 up 4.888
ACSS3 down -2.319 up 10.186
ACTC1 down -5.897 up 6.077
ADGRB3 down -2.684 up 2.683
ADGRG2 down -2.288 up 10.088
ADGRL3 down -2.878 up 11.992
ADM2 up 2.445 down -5.152
ADORA2B down -2.039 up 6.836
ADRA1D down -2.894 up 5.283
ADRA2B down -2.707 up 4.969
ADTRP down -8.97 up 9.663
AFF2 down -3.035 up 2.979
AGTR1 up 2.666 down -11.168
AHNAK2 down -3.358 up 15.334
AJAP1 down -2.963 up 5.326
AK5 up 4.007 down -4.402
AKR1B1 down -14.798 up 5.557
ALDH3A1 down -2.898 up 7.785
AMOT down -3.157 up 6.393
ANXA2P2 down -2.658 up 3.053
ANXA9 down -3.037 up 7.878
AOC3 down -2.13 up 10.728
AOX1 down -5.345 up 9.811
APBA2 up 2.258 down -7.364
APOB down -2.494 up 10.937
APOBEC3C down -4.149 up 2.166
APOBEC3F down -2.145 up 14.049
APOBEC3G down -3.812 up 4.06
APOC1 up 4.942 down -2.245
AQP2 down -637.47 up 2.927
ARHGEF28 down -2.095 up 3.762
ASPA down -4.257 up 2.01
ASPN up 3.519 down -4.89
ATP2B4 down -2.741 up 4.921
ATRNL1 down -3.093 up 3.558
AURKB up 2.903 down -8.933
BCO1 down -2.649 up 5.207
BDNF down -2.431 up 9.322
BHMT2 down -2.79 up 10.703
BIRC5 up 3.842 down -2.697
BNC1 down -2.558 up 6.139
BNC2 down -2.248 up 3.573
BUB1 up 2.573 down -6.06
C14orf132 down -2.463 up 6.157
C1QTNF1 down -3.092 up 14.632
C21orf62 down -5.628 up 9.238
C4orf19 down -2.494 up 2.084
C7 down -2.279 up 21.725
CAMK1G down -2.499 up 4.835
CAMK4 down -2.013 up 10.678
CAMKK2 up 3.176 down -4.98
CAND2 down -2.117 up 8.484
CAP2 down -2.139 up 7.085
CAPN6 down -4.558 up 8.244
CARTPT down -3.792 up 8.538
CASQ2 down -2.488 up 12.684
CAV1 down -3.292 up 6.45
CAV2 down -2.638 up 10.637
CAV3 down -2.223 up 10.243
CCDC181 down -2.409 up 7.566
CCL17 up 2.246 down -2.706
CCNA2 up 2.478 down -5.116
CD200 down -2.294 up 2.389
CD38 down -2.79 up 5.928
CD40 down -2.068 up 7.838
CDC42EP3 down -2.201 up 7.178
CDH15 up 2.613 down -2.411
CDH22 down -2.091 up 6.177
CDHR1 down -3.743 up 4.368
CDK18 down -3.385 up 6.62
CDKL2 down -2.641 up 12.388
CDO1 down -4.862 up 8.533
CEACAM6 down -2.848 up 12.358
CELSR3 up 3.383 down -3.355
CEND1 down -2.868 up 2.664
CENPA up 3.755 down -4.721
CERS4 up 2.051 down -2.243
CHAD down -2.139 up 8.905
CHP2 down -4.44 up 5.104
CHST3 down -2.175 up 6.545
CLDN1 down -2.048 up 12.901
CLDN3 up 2.203 down -14.396
CLIC4 down -2.039 up 7.041
CLIP4 down -2.218 up 4.309
CLSTN2 down -2.052 up 8.19
CNR1 down -2.026 up 11.451
CNTFR down -3.365 up 3.953
COL10A1 up 4.775 down -4.295
COL21A1 down -2.448 up 4.644
CORO2B down -2.551 up 8.882
CPB1 up 2.692 down -2.806
CPEB1 down -2.513 up 3.831
CPNE6 down -4.555 up 2.863
CRHBP down -2.828 up 4.197
CRLF1 up 2.162 down -4.441
CRTAC1 down -19.791 up 7.812
CSPG4 down -2.071 up 8.937
CSRP1 down -2.737 up 3.232
CST1 up 4.695 down -8.639
CST2 up 14.181 down -13.385
CXCL10 up 2.02 down -2.774
CXCL13 down -3.119 up 4.921
CXCL6 down -2.063 up 4.54
CYP27A1 down -2.083 up 14.003
CYP2E1 down -3.585 up 19.986
CYP2W1 down -2.416 up 6.873
CYP3A5 down -4.019 up 5.881
CYP4B1 down -4.508 up 6.785
DAB1 down -2.869 up 8.743
DAPP1 down -2.004 up 7.6
DCN down -2.041 up 7.188
DCSTAMP up 3.052 down -3.121
DDIT4 down -2.291 up 5.522
DDO down -2.142 up 8.133
DES down -2.76 up 3.697
DGCR9 up 3.654 down -4.891
DGKG down -2.652 up 16.689
DKK1 down -2.822 up 9.862
DKK3 down -2.066 up 13.444
DLK2 down -2.203 up 4.192
DLX2 up 9.489 down -9.389
DMBT1 down -4.804 up 6.429
DMD down -2.942 up 14.634
DNAJB4 down -2.421 up 6.296
DNAJB5 down -2.679 up 5.175
DNAJC15 down -2.454 up 5.952
DPYS down -2.65 up 7.698
DPYSL3 down -2.268 up 8.26
DRD2 down -3.01 up 4.049
DSG3 down -3.783 up 2.395
DTNA down -2.51 up 8.999
DUOX1 down -4.436 up 17.662
DZIP1 down -2.12 up 11.154
EDAR down -2.911 up 10.37
EDIL3 down -2.289 up 5.084
EDNRA down -2.492 up 2.399
EDNRB down -2.994 up 11.118
EFCAB1 down -2.016 up 2.84
EFEMP1 down -2.582 up 11.263
EFHC2 down -2.181 up 2.573
EFNB1 down -2.434 up 3.827
EGR4 up 3.914 down -2.67
ENTPD3 down -2.573 up 5.99
EPCAM up 2.156 down -2.903
EPHA2 down -3.781 up 6.223
ERN2 down -3.075 up 6.298
ESRP2 up 2.204 down -2.971
EYA4 down -3.284 up 5.144
EZH2 up 2.758 down -18.037
F2RL2 up 4.235 down -2.098
FASN up 2.622 down -7.607
FAT2 down -3.657 up 4.87
FAT4 down -2.253 up 9.698
FFAR2 up 3.452 down -6.98
FGFBP1 down -3.232 up 12.97
FHOD3 down -2.481 up 4.218
FLNC down -3.2 up 3.545
FLRT3 down -2.456 up 4.208
FOLR1 down -4.848 up 10.626
FOXF1 down -2.117 up 11.219
FUT3 down -17.439 up 10.484
FUT6 down -5.024 up 12.894
G0S2 down -4.894 up 3.844
GABRD up 3.674 down -3.63
GAD1 up 2.262 down -3.862
GATM down -2.688 up 19.511
GFRA2 down -3.114 up 7.533
GIPC2 down -2.348 up 5.609
GJB3 down -3.026 up 8.192
GJB4 down -4.335 up 7.569
GJB5 down -3.789 up 3.568
GJC1 down -2.262 up 10.65
GNAO1 down -5.666 up 13.956
GNG11 down -2.05 up 2.81
GOLM1 up 3.394 down -5.511
GPLD1 down -2.237 up 2.801
GPM6A down -3.135 up 7.744
GPR161 down -2.374 up 4.361
GPR37 up 2.41 down -2.142
GPR75 down -2.048 up 2.404
GPRASP1 down -2.141 up 5.808
GPX3 down -2.147 up 9.189
GSTM5 down -2.623 up 4.884
HAAO down -2.07 up 7.332
HAND2 down -2.175 up 8.378
HAND2-AS1 down -2.167 up 4.03
HECW1 down -2.545 up 5.421
HFE down -2.486 up 4.56
HHIPL2 down -2.318 up 23.29
HOXA7 down -2.359 up 12.055
HOXB2 down -3.272 up 2.805
HOXB7 down -5.896 up 2.528
HOXB9 down -13.626 up 5.756
HOXD13 down -3.449 up 6.401
HPD down -2.811 up 9.163
HPGD up 2.512 down -3.568
HPN up 5.672 down -2.746
HR down -2.099 up 5.061
HRH2 down -2.616 up 4.33
HS3ST3A1 down -2.442 up 12.951
HSD11B1 down -2.571 up 2.977
HSPB3 down -2.88 up 2.37
ID3 down -2.335 up 2.041
IER3 down -3.242 up 6.249
IL11 up 2.548 down -2.332
IL18R1 down -3.186 up 3.83
IL1RL1 down -4.471 up 5.502
IQSEC3 down -2.707 up 6.816
IRF5 down -2.625 up 8.876
IRF7 up 2.168 down -3.552
ISG15 up 3.999 down -11.047
ISYNA1 down -2.375 up 4.742
ITGA2 down -2.517 up 6.067
ITGA8 down -2.039 up 7.102
ITGA9 down -2.297 up 13.963
ITGB3 down -2.709 up 6.973
ITGB8 down -2.373 up 9.902
ITIH5 down -2.304 up 7.062
ITPR1 down -2.315 up 7.191
KCNC2 up 3.567 down -2.122
KCNJ16 down -40.317 up 2.648
KCNJ3 down -3.863 up 15.631
KCNJ5 down -8.76 up 12.782
KCNJ8 down -2.293 up 7.182
KCNK15 down -2.117 up 6.975
KCNK3 down -2.143 up 4.289
KCNMA1 down -2.601 up 5.046
KCNMB1 down -2.885 up 2.082
KCNQ1 down -3.739 up 2.743
KCNS1 down -6.79 up 14.941
KIF14 up 2.605 down -3.277
KIF2C up 2.12 down -3.494
KIFC1 up 2.651 down -7.915
KITLG down -2.421 up 2.657
KLK14 up 4.47 down -12.559
KRT13 down -7.86 up 3.721
KRT4 down -4.422 up 17.136
KRT6A down -2.962 up 8.013
KSR1 down -2.25 up 8.255
L1CAM down -2.405 up 11.222
LARGE down -2.276 up 3.505
LDB3 down -3.125 up 13.746
LIMS2 down -2.208 up 2.098
LIPC down -3.557 up 8.828
LIPG down -7.103 up 10.122
LMO3 down -4.537 up 3.927
LMOD1 down -3.082 up 2.939
LONRF3 down -2.621 up 10.689
LPA down -2.714 up 4.531
LPAR1 down -2.219 up 3.833
LRMP down -2.332 up 16.265
LRP4 down -2.159 up 2.555
LRRN3 down -2.838 up 4.079
LSAMP down -2.57 up 10.475
LY6D down -9.507 up 12.933
LYVE1 down -4.831 up 6.612
MAP1A down -2.882 up 2.209
MAP1B down -2.31 up 13.768
MARCO down -2.143 up 11.93
MASP1 down -2.625 up 6.465
MATK up 5.983 down -12.491
MBNL2 down -2.089 up 12.679
MCAM down -2.096 up 6.574
MCC down -2.543 up 7.216
MCCC2 up 2.393 down -7.238
ME1 down -3.542 up 5.37
MET down -2.077 up 4.597
METTL7A down -2.072 up 5.341
MICAL2 up 2.002 down -7.384
MME down -2.124 up 4.017
MMP1 down -2.179 up 16.51
MMP11 up 2.396 down -18.043
MPP2 down -2.729 up 8.974
MPZ down -2.793 up 15.724
MPZL2 down -2.05 up 18.556
MR1 down -2.228 up 11.298
MRPL12 up 2.05 down -2.147
MSLN down -6.384 up 3.577
MSMB down -2.145 up 10.259
MTG1 up 2.037 down -7.351
MTMR8 down -2.432 up 5.123
MUC13 up 2.637 down -8.882
MUC2 up 2.273 down -4.245
MYH11 down -3.429 up 7.981
MYH3 down -2.159 up 7.996
MYH6 down -5.756 up 8.16
MYL9 down -2.507 up 3.801
MYT1 up 3.74 down -6.007
MZB1 up 2.901 down -6.301
NCAM1 down -3.299 up 9.302
NCAPH up 2.716 down -4.882
NCS1 down -2.274 up 21.847
NDNF down -2.469 up 14.593
NEFH down -2.228 up 4.852
NKAIN1 up 4.774 down -9.982
NKX2-2 up 15.698 down -3.092
NMUR1 down -2.514 up 7.032
NOX1 down -3.087 up 7.945
NPY6R down -4.608 up 18.291
NRCAM down -2.434 up 2.11
NRG1 down -2.421 up 4.383
NRG2 down -2.967 up 10.647
NRP2 down -2.237 up 8.474
NRXN1 down -2.738 up 3.728
NTF3 down -2.15 up 13.419
NTRK1 down -2.225 up 5.846
NTRK3 down -2.162 up 22.255
NYNRIN down -3.769 up 6.593
ODAM down -2.196 up 8.176
P2RX1 down -2.887 up 8.061
P2RX2 down -3.554 up 3.609
PAK3 down -3.496 up 2.416
PAK7 down -3.365 up 2.627
PALLD down -2.79 up 3.993
PAOX up 2.019 down -9.431
PARM1 down -2.154 up 3.568
PAX2 down -17.122 up 12.053
PBK up 2.835 down -6.399
PCDHA10 up 2.578 down -2.549
PCSK1N up 2.299 down -4.119
PCSK2 down -2.812 up 4.367
PCYT1B down -2.807 up 3.599
PDE5A down -2.268 up 2.967
PDE7B down -3.187 up 2.427
PDGFC down -2.03 up 7.884
PDK4 down -8.221 up 10.884
PDLIM7 down -2.006 up 2.952
PDZRN4 down -3.157 up 3.191
PEAK1 down -2.29 up 16.831
PEG3 down -2.202 up 7.768
PGF down -2.691 up 6.977
PGM5 down -3.36 up 3.097
PILRB up 2.36 down -9.122
PINLYP down -2.108 up 8.105
PIPOX down -2.314 up 12.097
PITX1 down -2.152 up 15.104
PITX2 down -2.772 up 10.734
PLAG1 down -3.034 up 4.721
PLBD1 down -2.854 up 8.104
PLEKHA2 down -2.448 up 8.753
PLN down -2.451 up 10.457
PLP1 down -2.771 up 4.631
PLPPR1 up 3.288 down -4.436
PMP2 down -2.97 up 5.513
PNMA1 down -2.021 up 2.173
POPDC2 down -2.73 up 17.672
POU5F1B up 2.958 down -10.688
PPP1R12B down -2.456 up 15.023
PRDM8 down -3.128 up 5.946
PRKCA down -2.223 up 2.941
PRKG1 down -2.99 up 5.917
PRLR down -3.418 up 13.166
PRPH2 down -2.413 up 4.406
PRR36 up 3.443 down -11.675
PRRG4 down -2.223 up 12.614
PTGIS down -2.497 up 8.439
PTP4A3 up 2.779 down -3.779
QPRT down -5.319 up 4.152
RAB17 up 2.626 down -8.182
RAB38 down -2.758 up 4.443
RAB40A down -2.792 up 5.354
RAC3 up 2.52 down -9.138
RAP1GAP up 2.578 down -3.119
RASAL1 down -8.546 up 4.778
RASGRF1 down -2.721 up 5.827
RBFOX1 down -3.152 up 4.295
RBMS3 down -2.548 up 9.355
RBP1 down -2.764 up 2.597
RBPMS down -2.098 up 3.679
REEP1 down -2.242 up 23.624
REXO2 up 2.042 down -3.315
RGN down -2.354 up 12.924
RGS10 up 2.219 down -4.919
RGS11 up 3.354 down -9.236
RGS13 down -2.27 up 5.97
RGS9 down -2.384 up 2.214
RHCG down -4.043 up 14.624
RHOB down -2.075 up 2.862
RND3 down -2.315 up 2.504
ROBO1 down -2.201 up 10.638
RPE65 down -4.588 up 6.705
RSPH14 down -2.926 up 9.572
SBSPON down -4.87 up 9.619
SCARA3 down -3.363 up 4.388
SCGB1A1 down -5.573 up 6.7
SCN7A down -2.249 up 8.824
SCNN1D up 2.537 down -9.451
SCUBE3 down -2.172 up 12.12
SDPR down -2.557 up 4.546
SDS up 2.776 down -4.2
SEC23A down -2.148 up 10.252
SEMA5A down -2.166 up 4.453
SEMA6D down -3.257 up 7.833
SEMG2 down -735.211 up 2.14
SERPINA4 down -3.267 up 5.654
SERPINA5 down -111.519 up 7.339
SERPINB1 down -2.22 up 7.304
SERPINB3 down -2.339 up 4.963
SERPINF2 down -3.072 up 10.662
SFRP4 up 2.901 down -3.308
SFRP5 down -6.876 up 24.346
SGCA down -2.161 up 15.657
SGCE down -2.085 up 3.9
SGCG down -2.774 up 2.361
SGK1 down -2.173 up 4.604
SIM2 up 4.714 down -3.864
SKA1 up 2.467 down -5.535
SLC16A4 down -2.138 up 18.572
SLC25A10 up 2.212 down -3.188
SLC25A22 up 2.103 down -6.869
SLC2A4 down -2.309 up 3.761
SLC2A5 down -3.423 up 5.778
SLC2A9 down -6.56 up 9.388
SLC34A2 down -9.153 up 2.652
SLC43A1 up 2.882 down -9.107
SLC4A4 up 2.174 down -5.902
SLC52A1 down -2.821 up 4.581
SLCO2A1 down -3.363 up 10.721
SLIT1 up 7.824 down -14.391
SLITRK3 down -5.055 up 3.844
SMTN down -2.304 up 7.661
SNCG down -3.109 up 2.841
SOSTDC1 down -3.713 up 6.126
SOX5 down -2.115 up 10.301
SPAG5 up 2.261 down -7.016
SPARCL1 down -2.155 up 6.684
SPC25 up 2.813 down -4.357
SPINK1 up 18.915 down -2.771
SPON1 down -3.019 up 4.614
SSPN down -2.127 up 14.08
SST down -3.852 up 10.942
SSTR2 down -2.342 up 7.136
ST18 up 2.526 down -3.702
ST6GALNAC4 down -3.498 up 2.251
STAC down -5.261 up 3.451
STIL up 2.211 down -6.164
STK26 down -2.293 up 12.756
STXBP5L down -2.496 up 2.105
TACC1 down -2.026 up 5.02
TACR2 down -2.123 up 10.053
TAGLN down -2.549 up 6.293
TARBP1 up 2.067 down -3.084
TBX2 down -2.626 up 14.587
TBX4 down -4.529 up 11.168
TBX5 down -3.239 up 4.718
TENM1 up 3.604 down -4.356
TENM3 down -2.323 up 2.69
TFF3 up 9.702 down -3.623
TGFB1I1 down -2.414 up 9.958
TGM1 down -2.493 up 12.135
TIMP4 down -2.212 up 2.281
TINAGL1 down -2.295 up 7.396
TLR2 down -2.728 up 2.152
TMC5 up 2.315 down -3.352
TMEM100 down -3.594 up 2.624
TMEM132A up 3.237 down -2.309
TMEM35 down -3.796 up 2.543
TMEM40 down -3.356 up 12.291
TMEM47 down -2.037 up 11.548
TMOD1 down -2.061 up 3.57
TMOD2 down -2.07 up 9.324
TNS1 down -2.71 up 6.477
TNS4 down -2.988 up 4.125
TP53AIP1 down -2.689 up 5.376
TPM1 down -2.684 up 5.975
TPO up 3.419 down -4.666
TRHDE down -3.201 up 2.979
TRIB3 up 2.035 down -18.954
TRIM9 down -4.708 up 7.934
TRO down -2.165 up 5.095
TRPC6 down -2.787 up 2.653
TSPAN2 down -2.24 up 8.038
TUBB2A up 2.595 down -11.879
UNC5B down -4.668 up 5.777
VAX2 up 2.997 down -3.929
VTN down -2.937 up 9.575
WFDC1 down -2.272 up 5.423
WFDC2 down -4.909 up 5.601
WNT16 down -2.353 up 9.237
WWC3 down -2.626 up 2.614
YBX2 down -2.02 up 3.037
ZBTB7C down -2.545 up 10.165
ZDHHC11 up 2.821 down -10.15
ZEB2 down -2.083 up 5.266
ZFPM2 down -2.197 up 6.767
ZNF536 down -2.865 up 9.085
ZNF804A down -2.99 up 6.71
Enrichment Result
GO
PID
KEGG
REACTOME
Pathway Name P-value Reverse Num Hit Num Gene List
Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines
ART4 up 2.432 up 15.059
ASB9 up 2.319 up 17.983
BICD1 up 2.975 up 16.833
CACNB1 0 0 up 21.935
CHIT1 up 4.328 up 15.059
DPF1 0 0 down -19.63
EBF2 up 4.787 up 15.826
ENTPD5 up 2.322 up 15.338
GGCT 0 0 down -16.443
GJB1 up 2.686 up 16.785
GRPR up 4.19 up 15.396
ITGBL1 up 2.995 up 17.281
KIF25 up 4.07 up 16.265
LINC00115 up 2.295 up 18.219
NDRG2 down -2.479 down -15.801
NR4A3 down -2.395 down -16.02
OCA2 0 0 up 17.946
PLA2G2A up 3.469 up 16.491
PLA2G2D up 2.474 up 15
POLD4 0 0 up 17.869
PYGL down -2.293 down -23.756
RELN up 3.249 up 21.479
ROS1 0 0 up 15.652
RPGRIP1 up 2.168 up 16.206
SLC45A2 up 34.13 up 16.22
SNHG20 0 0 up 21.975
TDRD1 up 7.86 up 17.375
TTR up 4.137 up 16.022
ZNF516 down -2.426 down -15.55
Enrichment Result
GO
PID
KEGG
REACTOME
Pathway Name P-value Adverse num Hit num Gene List

reverse gene
Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines
adverse gene
Genes Fold change of
cancer samples vs. normal samples
Fold change of
compound treated vs. DMSO treated cell lines